A case of frontal neuropsychological and neuroimaging signs following multiple primary-blast exposure.
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2012-06
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Blast-related traumatic brain injury (TBI) from the Afghanistan and Iraq wars represents a significant medical concern for troops and veterans. To better understand the consequences of primary-blast injury in humans, we present a case of a Marine exposed to multiple primary blasts during his 14-year military career. The neuropsychological profile of this formerly high-functioning veteran suggested primarily executive dysfunction. Diffusion-tensor imaging revealed white-matter pathology in long fiber tracks compared with a composite fractional-anisotropy template derived from a veteran reference control group without TBI. This study supports the existence of primary blast-induced neurotrauma in humans and introduces a neuroimaging technique with potential to discriminate multiple-blast TBI.
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Hayes, Jasmeet Pannu, Rajendra A Morey and Larry A Tupler (2012). A case of frontal neuropsychological and neuroimaging signs following multiple primary-blast exposure. Neurocase, 18(3). pp. 258–269. 10.1080/13554794.2011.588181 Retrieved from https://hdl.handle.net/10161/10983.
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Rajendra A. Morey
Research in my lab is focused on brain changes associated with posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and other neuropsychiatric disorders. We apply several advanced methods for understanding brain function including functional MRI, structural MRI, diffusion tensor imaging, and genetic effects.
Larry A. Tupler
My principal research interest concerns brain-behavior relationships, both in
normals and in psychiatric populations. Methods of study include magnetic
resonance imaging (MRI) and spectroscopy (MRS), neuropsychological
investigations, psychopharmacological studies, cognitive-science paradigms,
and methodological inquiries. More specifically, topics of interest include
lesion and morphometric studies of discrete brain regions as they relate to
cognitive and other behavioral measures, pharmacodynamics, pharmacotherapy,
and psychometric investigations of reliability and validity. Gerontological
populations are of particular interest in relation to both normal and abnormal
aging, particularly dementia (e.g., Alzheimer's disease and vascular
dementia). Psychiatric disorders of particular interest include mood and
anxiety disorders.
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