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Browsing by Duke-affiliated Author "Lefkowitz, Robert J."

DukeSpace

Browsing by Duke-affiliated Author "Lefkowitz, Robert J."

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  • Neuropathic Pain Activates the Endogenous κ Opioid System in Mouse Spinal Cord and Induces Opioid Receptor Tolerance
    Caron, Marc G.; Lefkowitz, Robert J. (Society for Neuroscience, 2004-05)
    Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation (pSNL) is known to contribute to the neuropathic pain processes. Using a phosphoselective antibody [κ opioid receptor ...
  • Reciprocal In Vivo Regulation of Myocardial G Protein-Coupled Receptor Kinase Expression by b-Adrenergic Receptor Stimulation and Blockade
    Lefkowitz, Robert J.; Koch, Walter J.; Tomhave, Eric; Iaccarino, Guido (American Heart Association, 1998)
    Background—Impaired myocardial β-adrenergic receptor (βAR) signaling, including desensitization and functional uncoupling, is a characteristic of congestive heart failure. A contributing mechanism for this impairment may ...
  • Regulation of G protein-coupled receptor signaling by scaffold proteins
    Lefkowitz, Robert J. (American Heart Association, 2002-10)
    The actions of many hormones and neurotransmitters are mediated through stimulation of G protein–coupled receptors. A primary mechanism by which these receptors exert effects inside the cell is by association with ...
  • Trafficking of G Protein–Coupled Receptors
    Drake, Matthew; Shenoy, Sudha Kaup; Lefkowitz, Robert J. (American Heart Association, 2006-09)
    G protein–coupled receptors (GPCRs) play an integral role in the signal transduction of an enormous array of biological phenomena, thereby serving to modulate at a molecular level almost all components of human biology. ...
  • When 7 transmembrane receptors are not G protein–coupled receptors
    Rajagopal, Keshava; Lefkowitz, Robert J.; Rockman, Howard Allan (American Society for Clinical Investigation, 2005-11)
    Classically, 7 transmembrane receptors transduce extracellular signals by coupling to heterotrimeric G proteins, although recent in vitro studies have clearly demonstrated that they can also signal via G protein–independent ...
  • β-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial Hypertrophy
    Iaccarino, Guido; Dolber, Paul Christian; Lefkowitz, Robert J.; Koch, Walter J. (American Heart Association, 1999-01)
    Pressure overload ventricular hypertrophy is accompanied by dysfunctional β-adrenergic receptor signaling due to increased levels of the β-adrenergic receptor kinase-1, which phosphorylates and desensitizes β-adrenergic ...
  • β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice
    Walters, Robert William; Shukla, Arun Kumar; Kovacs, Jeffrey J.; Violin, Jonathan David; DeWire, Scott Matthew; Lam, Christopher; Chen, Ruthie; Muehlbauer, Mike; Whalen, Eric; Lefkowitz, Robert J. (American Society for Clinical Investigation, 2009-05)
    Nicotinic acid is one of the most effective agents for both lowering triglycerides and raising HDL. However, the side effect of cutaneous flushing severely limits patient compliance. As nicotinic acid stimulates the GPCR ...
  • β-Arrestin-2 regulates the development of allergic asthma
    Walker, Julia K.L.; Fong, Alan Michael; Lawson, Barbara; Savov, Jordan; Patel, Dhavalkumar Dhirajlal; Schwartz, David Albert; Lefkowitz, Robert J. (American Society for Clinical Investigation, 2003-08)
    Asthma is a chronic inflammatory disorder of the airways that is coordinated by Th2 cells in both human asthmatics and animal models of allergic asthma. Migration of Th2 cells to the lung is key to their inflammatory ...
  • β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection
    Noma, Takahisa; Lemaire, Anthony; Prasad, Sathyamangla V. Naga; Barki-Harrington, Liza; Tilley, Douglas; Chen, Juhsien; Le Corvoisier, Philippe; Violin, Jonathan David; Wei, Huijin; Lefkowitz, Robert J.; Rockman, Howard Allan (American Society for Clinical Investigation, 2007-09)
    Deleterious effects on the heart from chronic stimulation of β-adrenergic receptors (βARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl cyclase activation. ...
  • β-Arrestins Regulate Atherosclerosis and Neointimal Hyperplasia by Controlling Smooth Muscle Cell Proliferation and Migration
    Kim, Jihee; Zhang, Lisheng; Peppel, Karsten C.; Wu, Jiao-Hui; Zidar, David; Brian, Leigh; DeWire, Scott Matthew; Exum, Sabrina; Lefkowitz, Robert J.; Freedman, Neil Jonathan (American Heart Association, 2008-07)
    Atherosclerosis and arterial injury-induced neointimal hyperplasia involve medial smooth muscle cell (SMC) proliferation and migration into the arterial intima. Because many 7-transmembrane and growth factor receptors ...