DukeSpace Home
→
Browsing by Duke-affiliated Author

Browsing by Duke-affiliated Author "Montefiori, David Charles"

Now showing items 1-12 of 12

Analysis of Memory B Cell Responses and Isolation of Novel Monoclonal Antibodies with Neutralizing Breadth from HIV-1-Infected Individuals

Montefiori, David (PUBLIC LIBRARY SCIENCE, 2010)

Background: The isolation of human monoclonal antibodies (mAbs) that neutralize a broad spectrum of primary HIV-1 isolates and the characterization of the human neutralizing antibody B cell response to HIV-1 infection are ...
Comparative Immunogenicity of HIV-1 Clade C Envelope Proteins for Prime/Boost Studies

Montefiori, David (PUBLIC LIBRARY SCIENCE, 2010)

Background: Previous clinical efficacy trials failed to support the continued development of recombinant gp120 (rgp120) as a candidate HIV vaccine. However, the recent RV144 HIV vaccine trial in Thailand showed that a ...
Differential Inhibition of Human Immunodeficiency Virus Type 1 in Peripheral Blood Mononuclear Cells and TZM-bl Cells by Endotoxin-Mediated Chemokine and Gamma Interferon Production

Geonnotti, Anthony R.; Bilska, Mira; Yuan, Xing; Montefiori, David (MARY ANN LIEBERT INC, 2010)

Bacterial lipopolysaccharide ( endotoxin) is a frequent contaminant of biological specimens and is also known to be a potent inducer of beta-chemokines and other soluble factors that inhibit HIV-1 infection in vitro. Though ...
Genetic Signatures in the Envelope Glycoproteins of HIV-1 that Associate with Broadly Neutralizing Antibodies

Li, Ming; Tang, Haili; Greene, Kelli; Gao, Hongmei; Montefiori, David (PUBLIC LIBRARY SCIENCE, 2010)

A steady increase in knowledge of the molecular and antigenic structure of the gp120 and gp41 HIV-1 envelope glycoproteins (Env) is yielding important new insights for vaccine design, but it has been difficult to translate ...
HIV-1 Neutralization Profile and Plant-Based Recombinant Expression of Actinohivin, an Env Glycan-Specific Lectin Devoid of T-Cell Mitogenic Activity

Montefiori, David (PUBLIC LIBRARY SCIENCE, 2010)

The development of a topical microbicide blocking the sexual transmission of HIV-1 is urgently needed to control the global HIV/AIDS pandemic. The actinomycete-derived lectin actinohivin (AH) is highly specific to a cluster ...
Immunization with Cocktail of HIV-Derived Peptides in Montanide ISA-51 Is Immunogenic, but Causes Sterile Abscesses and Unacceptable Reactogenicity

Weinhold, Kent; Ottinger, Janet; Ferarri, Guido; Montefiori, David; Haynes, Barton (PUBLIC LIBRARY SCIENCE, 2010)

Background: A peptide vaccine was produced containing B and T cell epitopes from the V3 and C4 Envelope domains of 4 subtype B HIV-1 isolates (MN, RF, CanO, & Ev91). The peptide mixture was formulated as an emulsion in ...
Inhibition of Adaptive Immune Responses Leads to a Fatal Clinical Outcome in SIV-Infected Pigtailed Macaques but Not Vervet African Green Monkeys

Li, Ming; Tang, Haili; Montefiori, David (PUBLIC LIBRARY SCIENCE, 2009)

African green monkeys (AGM) and other natural hosts for simian immunodeficiency virus (SIV) do not develop an AIDS-like disease following SIV infection. To evaluate differences in the role of SIV-specific adaptive immune ...
Magnitude and Breadth of a Nonprotective Neutralizing Antibody Response in an Efficacy Trial of a Candidate HIV-1 gp120 Vaccine

Montefiori, David (UNIV CHICAGO PRESS, 2010)

Background. A candidate vaccine consisting of human immunodeficiency virus type 1 (HIV-1) subunit gp120 protein was found previously to be nonprotective in an efficacy trial (Vax004) despite strong antibody responses against ...
Neutralization activity in a geographically diverse East London cohort of human immunodeficiency virus type 1-infected patients: clade C infection results in a stronger and broader humoral immune response than clade B infection

Greene, Kelli; Gao, Hongmei; Montefiori, David (SOC GENERAL MICROBIOLOGY, 2010)

The array of human immunodeficiency virus (HIV) subtypes encountered in East London, an area long associated with migration, is unusually heterogeneous, reflecting the diverse geographical origins of the population. In ...
Potent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1

Montefiori, David (LANDES BIOSCIENCE, 2010)

Several human monoclonal antibodies (hmAbs) exhibit relatively potent and broad neutralizing activity against HIV-1, but there has not been much success in using them as potential therapeutics. We have previously hypothesized ...
Profiles of Human Serum Antibody Responses Elicited by Three Leading HIV Vaccines Focusing on the Induction of Env-Specific Antibodies

Montefiori, David (PUBLIC LIBRARY SCIENCE, 2010)

In the current report, we compared the specificities of antibody responses in sera from volunteers enrolled in three US NIH-supported HIV vaccine trials using different immunization regimens. HIV-1 Env-specific binding ...
R5 Clade C SHIV Strains with Tier 1 or 2 Neutralization Sensitivity: Tools to Dissect Env Evolution and to Develop AIDS Vaccines in Primate Models

Montefiori, David (PUBLIC LIBRARY SCIENCE, 2010)

Background: HIV-1 clade C (HIV-C) predominates worldwide, and anti-HIV-C vaccines are urgently needed. Neutralizing antibody (nAb) responses are considered important but have proved difficult to elicit. Although some current ...

Now showing items 1-12 of 12

Search DukeSpace

Advanced Search

Browse

All of DukeSpace

Browsing by Duke-affiliated Author "Montefiori, David Charles"

DukeSpace

Browsing by Duke-affiliated Author "Montefiori, David Charles"

Search DukeSpace

Browse

All of DukeSpace

My Account