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Browsing by Duke-affiliated Author "Caron, Marc G."

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Differential Mechanisms of Morphine Antinociceptive Tolerance Revealed in βArrestin-2 Knock-Out Mice

Bohn, Laura M.; Lefkowitz, Robert J.; Caron, Marc G. (Society for Neuroscience, 2002-12)

Morphine induces antinociception by activating μ opioid receptors (μORs) in spinal and supraspinal regions of the CNS. βarrestin-2 (βarr2), a G-protein-coupled receptor-regulating protein, regulates the μOR in vivo. We ...
The Dopamine Metabolite 3-Methoxytyramine Is a Neuromodulator

Sotnikova, Tatyana D.; Masri, Bernard; Salahpour, Ali; Barak, Larry S.; Caron, Marc; Gainetdinov, Raul (PUBLIC LIBRARY SCIENCE, 2010)

Dopamine (3-hydroxytyramine) is a well-known catecholamine neurotransmitter involved in multiple physiological functions including movement control. Here we report that the major extracellular metabolite of dopamine, ...
Enhanced Rewarding Properties of Morphine, but not Cocaine, in βarrestin-2 Knock-Out Mice

Gainetdinov, Raul Radikovich; Sotnikova, Tatyana; Medvedev, Ivan; Lefkowitz, Robert J.; Caron, Marc G. (Society for Neuroscience, 2003-11)

The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of μ-opioid receptors (μOR). Both μ-opioid and dopamine receptors are members of the G-protein-coupled ...
The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain

Arriza, Jeffrey; Dawson, Ted; Simerly, Richard; Martin, Lee; Caron, Marc G.; Snyder, Solomon; Lefkowitz, Robert J. (Society for Neuroscience, 1992-10)

The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating adenylyl cyclase activity. Beta ARK-mediated ...
Mechanisms of Membrane-Receptor Regulation — Biochemical, Physiological, and Clinical Insights Derived from Studies of the Adrenergic Receptors

Lefkowitz, Robert J.; Caron, Marc G.; Stiles, Gary Lester (Massachusetts Medical Society, 1984-06-14)
Neuropathic Pain Activates the Endogenous κ Opioid System in Mouse Spinal Cord and Induces Opioid Receptor Tolerance

Caron, Marc G.; Lefkowitz, Robert J. (Society for Neuroscience, 2004-05)

Release of endogenous dynorphin opioids within the spinal cord after partial sciatic nerve ligation (pSNL) is known to contribute to the neuropathic pain processes. Using a phosphoselective antibody [κ opioid receptor ...

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