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Browsing by Author "0121134"

DukeSpace

Browsing by Author "0121134"

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  • β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice
    Walters, Robert William; Shukla, Arun Kumar; Kovacs, Jeffrey J.; Violin, Jonathan David; DeWire, Scott Matthew; Lam, Christopher; Chen, Ruthie; Muehlbauer, Mike; Whalen, Eric; Lefkowitz, Robert J. (American Society for Clinical Investigation, 2009-05)
    Nicotinic acid is one of the most effective agents for both lowering triglycerides and raising HDL. However, the side effect of cutaneous flushing severely limits patient compliance. As nicotinic acid stimulates the GPCR ...
  • β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection
    Noma, Takahisa; Lemaire, Anthony; Prasad, Sathyamangla V. Naga; Barki-Harrington, Liza; Tilley, Douglas; Chen, Juhsien; Le Corvoisier, Philippe; Violin, Jonathan David; Wei, Huijin; Lefkowitz, Robert J.; Rockman, Howard Allan (American Society for Clinical Investigation, 2007-09)
    Deleterious effects on the heart from chronic stimulation of β-adrenergic receptors (βARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl cyclase activation. ...