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Browsing by Duke-affiliated Author "Ohler, Uwe"

DukeSpace

Browsing by Duke-affiliated Author "Ohler, Uwe"

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  • Evidence-ranked motif identification
    Georgiev, Stoyan; Boyle, Alan; Jayasurya, Karthik; Ding, Xuan; Mukherjee, Sayan; Ohler, Uwe (BIOMED CENTRAL LTD, 2010)
    cERMIT is a computationally efficient motif discovery tool based on analyzing genome-wide quantitative regulatory evidence. Instead of pre-selecting promising candidate sequences, it utilizes information across all sequence ...
  • Mapping the complexity of transcription control in higher eukaryotes
    Ohler, Uwe (BIOMED CENTRAL LTD, 2010)
    Recent genomic analyses suggest the importance of combinatorial regulation by broadly expressed transcription factors rather than expression domains characterized by highly specific factors.
  • Modeling the Evolution of Regulatory Elements by Simultaneous Detection and Alignment with Phylogenetic Pair HMMs
    Majoros, William; Ohler, Uwe (PUBLIC LIBRARY SCIENCE, 2010)
    The computational detection of regulatory elements in DNA is a difficult but important problem impacting our progress in understanding the complex nature of eukaryotic gene regulation. Attempts to utilize cross-species ...
  • Promoting developmental transcription
    Ohler, Uwe (COMPANY OF BIOLOGISTS LTD, 2010)
    Animal growth and development depend on the precise control of gene expression at the level of transcription. A central role in the regulation of developmental transcription is attributed to transcription factors that bind ...