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Browsing by Duke-affiliated Author "Goldstein, David Benjamin"

DukeSpace

Browsing by Duke-affiliated Author "Goldstein, David Benjamin"

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  • The Characterization of Twenty Sequenced Human Genomes
    Pelak, Kimberly; Shianna, Kevin; Ge, Dr Dongliang; Maia, Jessica; Zhu, Dr Mingfu; Smith, Jason P.; Cirulli, Liz; Fellay, Dr Jacques; Dickson, Sam; Gumbs, Curtis; Heinzen, Erin L.; Need, Anna; Ruzzo, Elizabeth K.; Singh, Dr A; Campbell, Christopher; Hong, Linda; Lornsen, Katharina A.; McKenzie, Alexander; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)
    We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals ...
  • Common Genetic Variation and the Control of HIV-1 in Humans
    Fellay, Dr Jacques; Ge, Dr Dongliang; Shianna, Kevin; Cirulli, Liz; Urban, Thomas; Gumbs, Curtis; Feng, Sheng; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2009)
    To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic ...
  • Determinants of Protection among HIV-Exposed Seronegative Persons: An Overview
    Goldstein, David (UNIV CHICAGO PRESS, 2010)
    Both clinical experience and a growing medical literature indicate that some persons who have been exposed to human immunodeficiency virus (HIV) infection remain uninfected. Although in some instances this may represent ...
  • Genome-Wide mRNA Expression Correlates of Viral Control in CD4+T-Cells from HIV-1-Infected Individuals
    Dang, Kristen; Fellay, Dr Jacques; Heinzen, Erin L.; Feng, Sheng; Shianna, Kevin; Ge, Dr Dongliang; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)
    There is great interindividual variability in HIV-1 viral setpoint after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining, genome-wide, ...
  • Host Determinants of HIV-1 Control in African Americans
    Pelak, Kimberly; Goldstein, David; Walley, Nicole; Fellay, Dr Jacques; Ge, Dr Dongliang; Shianna, Kevin; Gumbs, Curtis; Maia, Jessica; Cronin, Ken (UNIV CHICAGO PRESS, 2010)
    We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene ...
  • Host Genetics and HIV-1: The Final Phase?
    Fellay, Dr Jacques; Shianna, Kevin; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)
    This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been ...
  • Rare Variants Create Synthetic Genome-Wide Associations
    Dickson, Sam; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)
    Genome-wide association studies (GWAS) have now identified at least 2,000 common variants that appear associated with common diseases or related traits (http://www.genome.gov/gwastudies), hundreds of which have been ...
  • Screening the human exome: a comparison of whole genome and whole transcriptome sequencing
    Cirulli, Liz; Singh, Dr A; Shianna, Kevin; Ge, Dr Dongliang; Smith, Jason P.; Maia, Jessica; Heinzen, Erin L.; Goldstein, David (BIOMED CENTRAL LTD, 2010)
    Background: There is considerable interest in the development of methods to efficiently identify all coding variants present in large sample sets of humans. There are three approaches possible: whole-genome sequencing, ...
  • Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene
    Cirulli, Liz; Ge, Dr Dongliang; Shianna, Kevin; Smith, Jason P.; Maia, Jessica; Gumbs, Curtis; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)
    Although more than 2,400 genes have been shown to contain variants that cause Mendelian disease, there are still several thousand such diseases yet to be molecularly defined. The ability of new whole-genome sequencing ...