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Browsing by Duke-affiliated Author "Leong, Kam"

DukeSpace

Browsing by Duke-affiliated Author "Leong, Kam"

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  • Characterization of topographical effects on macrophage behavior in a foreign body response model.
    Chen, S; Jones, JA; Xu, Y; Low, HY; Anderson, JM; Leong, Kam (2010-05)
    Current strategies to limit macrophage adhesion, fusion and fibrous capsule formation in the foreign body response have focused on modulating material surface properties. We hypothesize that topography close to biological ...
  • Deformation of stem cell nuclei by nanotopographical cues
    Chalut, Kevin J.; Kulangara, Karina; Giacomelli, Michael G.; Wax, Adam; Leong, Kam (ROYAL SOC CHEMISTRY, 2010)
    Cells sense cues in their surrounding microenvironment. These cues are converted into intracellular signals and transduced to the nucleus in order for the cell to respond and adapt its function. Within the nucleus, structural ...
  • Development of universal antidotes to control aptamer activity.
    Oney, S; Lam, RT; Bompiani, KM; Blake, CM; Quick, G; Heidel, JD; Liu, JY; Mack, BC; Davis, ME; Leong, Kam; Sullenger, Bruce Alan (2009-10)
    With an ever increasing number of people taking numerous medications, the need to safely administer drugs and limit unintended side effects has never been greater. Antidote control remains the most direct means to counteract ...
  • Implantation of Mouse Embryonic Stem Cell-Derived Cardiac Progenitor Cells Preserves Function of Infarcted Murine Hearts
    Christoforou, Nicolas; Bian, Weining; Bursac, Nenad; Leong, Kam (PUBLIC LIBRARY SCIENCE, 2010)
    Stem cell transplantation holds great promise for the treatment of myocardial infarction injury. We recently described the embryonic stem cell-derived cardiac progenitor cells (CPCs) capable of differentiating into ...
  • Quantum dot-based theranostics
    Ho, Yi-Ping; Leong, Kam (ROYAL SOC CHEMISTRY, 2010)
    Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have advanced the fields of molecular diagnostics and nanotherapeutics. Much of the initial progress for QDs in biology and medicine has focused on ...
  • Quantum dot-based theranostics
    Ho, Yi-Ping; Leong, Kam (2010)
    Luminescent semiconductor nanocrystals, also known as quantum dots (QDs), have advanced the fields of molecular diagnostics and nanotherapeutics. Much of the initial progress for QDs in biology and medicine has focused on ...
  • Simultaneous non-invasive analysis of DNA condensation and stability by two-step QD-FRET
    Chen, H; Ho, Y; Jiang, X; Mao, H; Wang, TH; Leong, Kam (2009)
    Nanoscale vectors comprised of cationic polymers that condense DNA to form nanocomplexes are promising options for gene transfer. The rational design of more efficient nonviral gene carriers will be possible only with ...