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Browsing by Author "0412985"

DukeSpace

Browsing by Author "0412985"

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  • The Characterization of Twenty Sequenced Human Genomes
    Pelak, Kimberly; Shianna, Kevin; Ge, Dr Dongliang; Maia, Jessica; Zhu, Dr Mingfu; Smith, Jason P.; Cirulli, Liz; Fellay, Dr Jacques; Dickson, Sam; Gumbs, Curtis; Heinzen, Erin L.; Need, Anna; Ruzzo, Elizabeth K.; Singh, Dr A; Campbell, Christopher; Hong, Linda; Lornsen, Katharina A.; McKenzie, Alexander; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)
    We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals ...
  • Common Genetic Variation and the Control of HIV-1 in Humans
    Fellay, Dr Jacques; Ge, Dr Dongliang; Shianna, Kevin; Cirulli, Liz; Urban, Thomas; Gumbs, Curtis; Feng, Sheng; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2009)
    To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic ...
  • Genome-Wide mRNA Expression Correlates of Viral Control in CD4+T-Cells from HIV-1-Infected Individuals
    Dang, Kristen; Fellay, Dr Jacques; Heinzen, Erin L.; Feng, Sheng; Shianna, Kevin; Ge, Dr Dongliang; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)
    There is great interindividual variability in HIV-1 viral setpoint after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining, genome-wide, ...
  • Host Determinants of HIV-1 Control in African Americans
    Pelak, Kimberly; Goldstein, David; Walley, Nicole; Fellay, Dr Jacques; Ge, Dr Dongliang; Shianna, Kevin; Gumbs, Curtis; Maia, Jessica; Cronin, Ken (UNIV CHICAGO PRESS, 2010)
    We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene ...
  • Host Genetics and HIV-1: The Final Phase?
    Fellay, Dr Jacques; Shianna, Kevin; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)
    This is a crucial transition time for human genetics in general, and for HIV host genetics in particular. After years of equivocal results from candidate gene analyses, several genome-wide association studies have been ...