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Browsing by Duke Department "Genetics and Genomics"

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Genetic Dissection of Chiari Type I Malformation

Markunas, Christina Ann (2013)

Chiari Type I Malformation (CMI) is a developmental disorder characterized by displacement of the cerebellar tonsils below the base of the skull, resulting in significant neurologic morbidity. While there are multiple ...
Genetic Modifiers in Response to Ischemia

Keum, Sehoon (2010)

In a mouse model of ischemic stroke, infarct volume is highly variable and strain dependent, but the natural genetic determinants responsible for this difference remain unknown. To identify genetic determinants regulating ...
Genetic Predictability Accompanies the Repeated Evolution of Red Flowers in Penstemon

Wessinger, Carolyn Alyson (2013)

Examining the genetic basis across repeated origins of the same phenotypic adaptation allows us to address several questions pertaining to the genetic basis of adaptation. First, whether the genes and types of mutations ...
Genetics Analysis of Standing Variation for Floral Morphology and Fitness Components in a Natural Population of Mimulus Guttatus (Common Monkeyflower)

Lee, Young Wha (2009)

An unresolved problem in evolutionary biology is the nature of forces that maintain standing variation for quantitative traits. In this study we take advantage of newly developed genomic resources to understand how ...
Genome-Wide Analyses of HIV-1 Host Genetics

Pelak, Kimberly (2012)

HIV has presented some of the greatest biomedical challenges in recent decades, and an understanding of how the virus behaves when it is in the human body is critical to addressing many of these challenges. One avenue ...
Genome-wide Cross-species Analysis Linking Open Chromatin, Differential Expression and Positive Selection

Shibata, Yoichiro (2012)

Deciphering the molecular mechanisms driving the phenotypic differences between humans and primates remains a daunting challenge. Mutations found in protein coding DNA alone has not been able to explain these phenotypic ...
Genomic Analysis of Pathway Signaling in Glioblastoma and Other Cancers

Reeves, Jason Windham (2012)

The disease process giving rise to cancer involves the consecutive accumulation of genetic or genomic alterations impacting the normal regulation of cellular functions. In cases of hereditary cancers, this process may ...
Genomic characterization and comparative analysis of the Xce candidate region

Sheedy, Christina B. (2012)

Mechanisms of sex chromosome dosage compensation vary widely between different vertebrate species. All eutherians, including humans, other primates, and rodents, undergo random X chromosome inactivation in early female ...
A Genomic Definition of Centromeres in Complex Genomes

Hayden, Karen Elizabeth (2011)

Centromeres, or sites of chromosomal spindle attachment during mitosis and meiosis, are non-randomly distributed in complex genomes and are largely associated with expansive, near-identical satellite DNA arrays. While ...
Genomic Signatures of Disease and Environmental Exposure in the Peripheral Blood

LaBreche, Heather Garren (2011)

My thesis research has centered on the concept of the peripheral blood cell (PBC) as an indicator of disease and environmental exposure. The PBC is not only easily accessible and constantly replenished, but it provides ...
High Resolution Transcriptional Profiling and Characterization of Cellular Inclusions in Arabidopsis thaliana Roots Grown in Low Sulfur Conditions

Jackson, Terry Lynell (2013)

Environmental stress affects plant development and productivity. Sulfur deficiency is a key nutrient deficiency that adversely affects crop yield. The model plant Arabidopsis thaliana has played an informative role in ...
Hybrid Sterility and Segregation Distortion in Drosophila pseudoobscura and Drosophila persimilis

McDermott, Shannon (2012)

Speciation has occurred countless times throughout history, and yet the genetic mechanisms that lead to speciation are still missing pieces. Here, we describe the genetics of two processes that can act alone or together ...
Identification of Mutations That Cause a Phenotypically and Genetically Heterogeneous Disorder, Muscular Dystrophy

McDonald, Kristin Kimberly (2013)

Muscular dystrophy is a devastating disease for which no cures or preventative treatments are currently available. There has been great progress in the identification of genetic mutations that cause some forms of muscle ...
Identification of Novel Imprinted Domains in the Therian Lineage

Das, Radhika (2010)

Genomic imprinting is the parent-of-origin dependent monoallelic expression of select developmentally important genes that are regulated by epigenetic mechanisms. It is believed to have co-evolved with placentation in ...
Imaging the Cell-Basement Membrane Interface during Anchor Cell Invasion in C. elegans

Hagedorn, Elliott Jennings (2012)

Basement membrane (BM) is the thin, dense, highly cross-linked form of extracellular matrix that underlies all epithelia and endothelia, as well as surrounds muscle, nerve and fat. These sheet-like networks function ...
Inhibition of Nucleolar Proteins in <italic>Caenorhabditis Elegans</Italic> Confers Enhanced Resistance to <italic>Salmonella Enterica</Italic> through a P53/<Italic>cep-1</Italic>-Dependent Mechanism

Fuhrman, Laura Elizabeth (2009)

The relatively simple innate immune system of <italic>Caenorhabditis elegans</italic> and the number of traits that facilitate genetic and genomic analysis using this organism have nurtured rapid advances into the ...
Integrating genetics, geography, and local adaptation to understand ecotype formation in the yellow monkeyflower, Mimulus guttatus

Lowry, David Bryant (2010)

Speciation is a constantly ongoing process whereby reproductive isolating baririer build up over time until groups of organisms can no longer exchange genes with each other. Adaptation is thought to play a major role ...
INVESTIGATION OF GENETIC FACTORS DETERMINING ISCHEMIC STROKE OUTCOME

CHU, PEI-LUN (2013)

Cerebrovascular disease (stroke), especially ischemic stroke, is a major cause of death and neurological disability in adults. Because of its clinical heterogeneity, stroke is considered as a multi-factorial and polygenic ...
Investigation of the Molecular Mechanism for Cerebral Cavernous Malformations

Akers, Amy Lee (2009)

Cerebral cavernous malformations (CCM) are vascular anomalies of the central nervous system comprised of grossly-dilated blood-filled capillaries. CCM leisons may occur sporadically or by inheritance of a mutation in ...
Leveraging Complementary In Vivo and In Vitro Gene Expression Measurements to Elucidate Uniquely Human Metabolic Processes

Pfefferle, Lisa Warner (2012)

The origin of man has motivated researchers to investigate differences between humans and our non-human relatives. The striking phenotypic differences that distinguish humans from chimpanzees are likely controlled by ...

Now showing items 21-40 of 70

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