Browsing by Duke-affiliated Author "Kuan, Chien-Tsun"

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Detection of Amino-terminal Extracellular Domain of Somatostatin Receptor 2 by Specific Monoclonal Antibodies and Quantification of Receptor Density in Medulloblastoma

Kuan, Chien-Tsun; Wikstrand, Carol J.; McLendon, Roger; Bigner, Darell (MARY ANN LIEBERT INC, 2009)

Somatostatin receptor 2 (SSTR2) is expressed by most medulloblastomas (MEDs). We isolated monoclonal antibodies (MAbs) to the 12-mer (33)QTEPYYDLTSNA(44), which resides in the extracellular domain of the SSTR2 amino terminus, ...
MRP3: a molecular target for human glioblastoma multiforme immunotherapy

Kuan, Chien-Tsun; Wakiya, Kenji; Pegram, Charles; Rasheed, Ahmed; Szafranski, Scott; McLendon, Roger; Bigner, Darell (BIOMED CENTRAL LTD, 2010)

Background: Glioblastoma multiforme (GBM) is refractory to conventional therapies. To overcome the problem of heterogeneity, more brain tumor markers are required for prognosis and targeted therapy. We have identified and ...
Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase-a key enzyme in lacto-neolacto ganglioside synthesis

Kuan, Chien-Tsun; Chang, Jinli; Li, Jianjun; Pegram, Charles; McLendon, Roger; Bigner, Darell (BIOMED CENTRAL LTD, 2010)

Background: Ganglioside biosynthesis occurs through a multi-enzymatic pathway which at the lactosylceramide step is branched into several biosynthetic series. Lc3 synthase utilizes a variety of galactose-terminated glycolipids ...

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