Browsing by Duke-affiliated Author "Fitzgerald, Michael C."

Now showing items 1-2 of 2

Mass Spectrometry-Based Thermal Shift Assay for Protein-Ligand Binding Analysis

West, Graham M.; DeArmond, Patrick D.; Fitzgerald, Michael (AMER CHEMICAL SOC, 2010)

Described here is a mass spectrometry-based screening assay for the detection of protein ligand binding interactions in multicomponent protein mixtures. The assay utilizes an oxidation labeling protocol that involves using ...
Thermodynamic Analysis of a Molecular Chaperone Binding to Unfolded Protein Substrates

Xu, Ying; Tang, Liangjie; Fitzgerald, Michael (AMER CHEMICAL SOC, 2010)

Molecular chaperones are a highly diverse group of proteins that recognize and bind unfolded proteins to facilitate protein folding and prevent nonspecific protein aggregation. The mechanisms by which chaperones bind their ...

Now showing items 1-2 of 2

Search DukeSpace