Arriza, Jeffrey; Dawson, Ted; Simerly, Richard; Martin, Lee; Caron, Marc G.; Snyder, Solomon; Lefkowitz, Robert J.
(Society for Neuroscience, 1992-10)
The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating adenylyl cyclase activity. Beta ARK-mediated ...