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Mice with Alopecia, Osteoporosis, and Systemic Amyloidosis Due to Mutation in Zdhhc13, a Gene Coding for Palmitoyl Acyltransferase

Chen, Yuan-Tsong (PUBLIC LIBRARY SCIENCE, 2010)

Protein palmitoylation has emerged as an important mechanism for regulating protein trafficking, stability, and protein protein interactions; however, its relevance to disease processes is not clear. Using a genome-wide, ...
Porcine Endothelial Cells Cocultured with Smooth Muscle Cells Became Procoagulant In Vitro

Pang, Zhengyu; Niklason, Laura E.; Truskey, George (MARY ANN LIEBERT INC, 2010)

Endothelial cell (EC) seeding represents a promising approach to provide a nonthrombogenic surface on vascular grafts. In this study, we used a porcine EC/smooth muscle cell (SMC) coculture model that was previously developed ...
Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential

Batinic-Haberle, Ines (MARY ANN LIEBERT INC, 2010)

Oxidative stress has become widely viewed as an underlying condition in a number of diseases, such as ischemia-reperfusion disorders, central nervous system disorders, cardiovascular conditions, cancer, and diabetes. Thus, ...
Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth

Wickman, Sarah; Eyler, Christine; Shi, Qing (PUBLIC LIBRARY SCIENCE, 2010)

Glioblastomas are deadly cancers that display a functional cellular hierarchy maintained by self-renewing glioblastoma stem cells (GSCs). GSCs are regulated by molecular pathways distinct from the bulk tumor that may be ...

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