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Browsing by Subject "susceptibility"

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Association between DNA Damage Response and Repair Genes and Risk of Invasive Serous Ovarian Cancer

Schildkraut, Joellen; Moorman, Patricia (PUBLIC LIBRARY SCIENCE, 2010)

Background: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), ...
Contributions of Mamu-A*01 Status and TRIM5 Allele Expression, But Not CCL3L Copy Number Variation, to the Control of SIVmac251 Replication in Indian-Origin Rhesus Monkeys

Haynes, Barton (PUBLIC LIBRARY SCIENCE, 2010)

CCL3 is a ligand for the HIV-1 co-receptor CCR5. There have recently been conflicting reports in the literature concerning whether CCL3-like gene (CCL3L) copy number variation (CNV) is associated with resistance to HIV-1 ...
Determinants of Protection among HIV-Exposed Seronegative Persons: An Overview

Goldstein, David (UNIV CHICAGO PRESS, 2010)

Both clinical experience and a growing medical literature indicate that some persons who have been exposed to human immunodeficiency virus (HIV) infection remain uninfected. Although in some instances this may represent ...
Genome-Wide Scan of Copy Number Variation in Late-Onset Alzheimer's Disease

Heinzen, Erin L. (IOS PRESS, 2010)

Alzheimer's disease is a complex and progressive neurodegenerative disease leading to loss of memory, cognitive impairment, and ultimately death. To date, six large-scale genome-wide association studies have been conducted ...
Host Determinants of HIV-1 Control in African Americans

Pelak, Kimberly; Goldstein, David; Walley, Nicole; Fellay, Dr Jacques; Ge, Dr Dongliang; Shianna, Kevin; Gumbs, Curtis; Maia, Jessica; Cronin, Ken (UNIV CHICAGO PRESS, 2010)

We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene ...
Quantitative Magnetic Susceptibility of the Developing Mouse Brain

Argyridis, Ioannis (2012)

Cerebral development involves a complex cascade of events which are difficult to visualize in vivo. In this study we combine information from Diffusion Tensor Imaging (DTI) and Quantitative Susceptibility ...
Rare Variants Create Synthetic Genome-Wide Associations

Dickson, Sam; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)

Genome-wide association studies (GWAS) have now identified at least 2,000 common variants that appear associated with common diseases or related traits (http://www.genome.gov/gwastudies), hundreds of which have been ...
Risk of Ovarian Cancer and Inherited Variants in Relapse-Associated Genes

Berchuck, Andrew; Iversen, Edwin; Schildkraut, Joellen (PUBLIC LIBRARY SCIENCE, 2010)

Background: We previously identified a panel of genes associated with outcome of ovarian cancer. The purpose of the current study was to assess whether variants in these genes correlated with ovarian cancer risk. Methods ...

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