Browsing by Subject "vaccines"

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An alphavirus vector overcomes the presence of neutralizing antibodies and elevated numbers of Tregs to induce immune responses in humans with advanced cancer

Morse, Michael (AMER SOC CLINICAL INVESTIGATION INC, 2010)

Therapeutic anticancer vaccines are designed to boost patients' immune responses to tumors. One approach is to use a viral vector to deliver antigen to in situ DCs, which then activate tumor-specific T cell and antibody ...
Potent and broad neutralizing activity of a single chain antibody fragment against cell-free and cell-associated HIV-1

Montefiori, David (LANDES BIOSCIENCE, 2010)

Several human monoclonal antibodies (hmAbs) exhibit relatively potent and broad neutralizing activity against HIV-1, but there has not been much success in using them as potential therapeutics. We have previously hypothesized ...
Transmission of Single HIV-1 Genomes and Dynamics of Early Immune Escape Revealed by Ultra-Deep Sequencing

Haynes, Barton (PUBLIC LIBRARY SCIENCE, 2010)

We used ultra-deep sequencing to obtain tens of thousands of HIV-1 sequences from regions targeted by CD8+ T lymphocytes from longitudinal samples from three acutely infected subjects, and modeled viral evolution during ...

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