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Browsing Electronic Theses and Dissertations by Duke Department

Browsing Electronic Theses and Dissertations by Duke Department "Chemistry"

Now showing items 21-40 of 80

Direct Carbon--Carbon Bond Formation Through Reductive Soft-Enolization of α-Halothioesters and The Total Synthesis of (+)-Mefloquine

Sauer, Scott J. (2011)

The direct addition of enolizable aldehydes and sulfonyl imines to α-halo thioesters to produce β-hydroxy/amino thioesters enabled by reductive soft enolization is reported. The transformation is operationally ...
Direct Carbon-Carbon Bond Formation via Base Mediated and Reductive Soft Enolization of Thioesters, the First Asymmetric Total Synthesis of (+)- and (-)-Clusianone, and Progress Toward the Asymmetric Total Synthesis of Brasilicardin A

Garnsey, Michelle Renee (2012)

Three methodology studies and two total synthesis endeavors are presented. First, a study of Lewis acid and hydrogen bond mediated soft enolization of thioesters and their addition to imines in the Mannich reaction is ...
Efforts to Elucidate the Binding Interaction between Lysine-Specific Demethylase 1 (LSD1/KDM1) and CoREST and Their Roles in Breast Cancer

HWANG, SUNHEE (2012)

Histone modifications play important roles in regulating gene expression in various cellular processes by altering the underlying chromatin structure and thus influencing related pathological conditions. Histone methylation ...
Equilibrium and Non-equilibrium Monte Carlo Simulations of Microphases and Cluster Crystals

Zhang, Kai (2012)

Soft matter systems exhibiting spatially modulated patterns on a mesoscale are characterized by many long-lived metastable phases for which relaxation to equilibrium is difficult and a satisfactory thermodynamic description ...
Examination of the Role of Lysine Specific Demethylase 1 (LSD1) and Associated Proteins in Breast Cancer Proliferation using 2-Phenylcyclopropylamine Inhibitors

Pollock, Julie Ann (2011)

Lysine specific demethylase 1 (LSD1) is a FAD-dependent amine oxidase enzyme responsible for removing methyl groups from the side chain nitrogen of lysine within histones in order to regulate gene transcription. By its ...
Excited State Dynamics of Conjugated Metalloporphyrins

Cleveland, Laura (2010)

The goal of this review is to highlight the unique and interesting aspects of conjugated metalloporphyrins. I will show the fundamental importance of these conjugated porphyrin systems by reviewing the excited state ...
Expanding the Scope of Mechanically Active Polymers

Klukovich, Hope (2012)

The addition of mechanically active functional groups (mechanophores) to polymer scaffolds has resulted in new chemical transformations and materials properties. The novel functions in these polymers are achieved in ...
Exploring Breast Cancer Risk Using NMR Metabonomics: Interstitial Breast Fluid and Breast Cancer Biomarkers

Reese, Rachel (2011)

For women with a high risk of developing breast cancer, the treatment options can be drastic, unnecessary, and emotionally and physically scarring. While histological evaluation of tissue samples is reliable for invasive ...
Exploring the Immunogenicity and Therapeutic Applications of Boranophosphate-modified RNA: siRNA and RNA Aptamers

Sharaf, Mariam Lucila (2011)

Borane (BH3) chemistry offers unique chemical characteristics that enable boranophosphate (BP) oligonucleotides with potential to enhance RNA therapeutic applications such as RNA interference (RNAi) and RNA ...
Gold(I) and Platinum(II)-Catalyzed Hydrofunctionalization of Allenes and Alkenes with Carbon and Nitrogen Nucleophiles

Butler, Kristina LeAnne (2012)

The wide-spread occurrence of biologically active nitrogen-containing heterocycles and allylic amines inspired us to develop atom-economical methods for their syntheses.A cationic gold(I) <italic>N</i ...
Gold(I)-Catalyzed Dehydrative Amination and Etherification of Allylic Alcohols

Mukherjee, Paramita (2012)

Allylic amines are important and fundamental building blocks due to their wide-spread occurrence in many natural products and the ability to further functionalize them by transformations on the double bond to generate ...
Gold(I)-Catalyzed Enantioselective Hydroamination of Unactivated Alkenes

Lee, seong du (2012)

Numerous methodologies for efficient formation of carbon-nitrogen bonds have been developed over the decades due to the widespread importance of nitrogen containing compounds in pharmaceuticals and bulk commercial ...
Gold(I)-Catalyzed Hydrofunctionilzations of Allenes with Nitrogen and Oxygen Nucleophiles

Duncan, Alethea (2011)

The importance of nitrogen-containing compounds in human life has drawn us to focus on the preparation of amine derivatives, combined with the limitations associated with traditional methods for the formation of C-N ...
I. Formal Synthesis of SCH 351448. II. Synthesis and Characterization of Largazole Analogues.

Park, Heekwang (2012)

Part I: Extensive studies for treating hypercholesterolemia, one of the major causes of human morbidity throughout the world, have led to the development of statin drugs-the most prevalent drug prescribed today. In ...
Inkless Soft Lithography: Utilizing Immobilized Enzymes and Small Molecules to Pattern Self-Assembled Monolayers Via Catalytic Microcontact Printing

Vogen, Briana Noelle (2010)

During the past two decades, soft lithographic techniques that circumvent the limitations of photolithography have emerged as important tools for the transfer of patterns with sub-micron dimensions. Among these techniques, ...
Insights into Chlamydial Protease-Like Activity Factor (CPAF)

Bednar, Maria Michelle (2011)

During infection of epithelial cells, the obligate intracellular pathogen Chlamydia trachomatis secretes the serine protease chlamydial protease-like activity factor (CPAF) into the host cytosol to regulate a range of ...
Insights into the Structure and Mechanism of Anhydromuramic Acid Kinase (AnmK): A Novel Peptidoglycan Recycling Enzyme with Dual Hydrolase and Kinase Functionality

Allen, Catherine Leigh (2011)

Bacteria recycle pre-existing peptidoglycan in order to minimize the de novo synthesis of peptidoglycan precursors. The recycling pathway is under study for its chemotherapeutic target potential. Anhydromuramic acid ...
Insights into the Synthesis, Mechanism of Action, and Biosynthesis of a Novel Lipodepsipeptide Antibiotic, WAP-8294A2

Blackledge, Meghan Scobee (2011)

In the last two decades, bacterial infections have reemerged as a serious public health threat. In the United States, nosocomial infections alone cost several billion dollars and are responsible for 100,000 deaths ...
Intrinsic Nonlinear Microscopy: From Neuronal Firing to Historical Artwork

Samineni, Prathyush (2012)

Imaging based on nonlinear processes takes advantage of the localized excitation to achieve high spatial resolution, optical sectioning, and deeper penetration in highly scattering media. However, the use of nonlinear ...
I. Studies Towards the Synthesis of Manassantins A and B and Analogues II. Efforts Towards a FRET-Based Assay to Characterize Palmitoylation of Src Kinases III. Synthesis of Oxepanes via Organocatalytic Oxa-Michael Reactions

Kasper, Amanda Clare (2010)

This dissertation focuses on three main projects that include aspects of natural product synthesis, synthetic methodology, as well as the development of a small molecular probe for the study of protein palmitoylation. ...