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Browsing Electronic Theses and Dissertations by Duke Department

Browsing Electronic Theses and Dissertations by Duke Department "Chemistry"

Now showing items 1-20 of 80

The Anti Selective Aldol Addition of Ketones to Aldehydes Mediated by N-Amino Cyclic Carbamate Chiral Auxiliaries and Its Use in the Asymmetric Total Synthesis of (+)- and (-)-Mefloquine Hydrochloride

Knight, John D. (2012)

In the first part of this dissertation, the first asymmetric anti selective aldol addition of a ketone-derived donor that is independent of the structure of the ketone is described. This transformation is facilitated ...
Application and Evaluation of a Chemical Modification- and Mass Spectrometry-Based Thermodynamic Assay for the Study of Protein-Ligand Interactions in Complex Mixtures

Strickland, Erin Catherine (2013)

While a number of different proteomic, genomic, and computational approaches exist for the characterization of drug action, each of the experimental approaches developed to date has both strengths and weaknesses. ...
Applications of Photoemission Electron Microscopy to Melanin and Melanosomes

Peles, Dana Nicole (2011)

Melanin is a biological pigment that is ubiquitous in nature and generally produced within melanosomes, specialized organelles. Typically, melanin is categorized into two distinct classes, based on color and molecular ...
Biophysical Investigations of Boranophosphate siRNA for Use in RNA Interference against Human Disease

Moussa, Laura (2009)

This project is predicated on the ability of the boranophosphate modification of siRNA to increase its therapeutic applicability for gene silencing in in vitro and in vivo systems. It has been shown that the boranophosphate ...
Boranophosphate-Modified Nucleic Acids as Biomolecular Probes: Synthesis, Substrate, and Antiviral Properties

Cheek, Marcus Adrian (2011)

In boranophosphate (BP) nucleotides, a borane (BH3) group is substituted for a non-bridging phosphoryl oxygen of a normal phosphate group, resulting in a class of modified isoelectronic DNA and RNA mimics that can ...
Characterization of Metal Binding Peptides Derived from Copper Trafficking Proteins

Rubino, Jeffrey Tyler (2010)

Copper was first released into the environment as the result of the mass generation of oxygen from photosynthetic bacteria roughly 2.7 billion years ago. While it proved to be poisonous to early life on Earth, those ...
Chemical Reactions and Self-assembly in Nano-confined Environments: the Development of New Catalytic Microcontact Printing Techniques and Multicomponent Inorganic Janus Particles

Shestopalov, Alexander A. (2009)

Modern patterning and fabrication techniques provide powerful opportunities for the preparation of micro- and nanostructured objects with applications in fields ranging from drug delivery and bioimaging to organic based ...
Copper at the Interface of Chemistry and Biology: New Insights into hCtr1 Function and the Role of Histidine in Human Cellular Copper Acquisition

Haas, Kathryn Louise (2010)

Mechanisms of copper homeostasis are of great interest partly due to their connection to debilitating genetic and neurological disorders. The family of high-affinity copper transporters (Ctr) is responsible for extracellular ...
A Covalent Modification Technique for Protein-Ligand Binding Analysis Using Mass Spectrometry-Based Proteomics Platforms

West, Graham Meldahl (2009)

Currently there is a dearth of analytical techniques for studying protein-ligand interactions on the proteomic scale. Existing techniques, which rely on various calorimetry or spectroscopy methods, are limited in their ...
The Design and Synthesis of Novel Chiral Z-Nitrones with Applications Towards the Syntheses of Enantiomerically Pure 4-Hydroxy Amino Acids

Stanko, John A (2009)

A number of 4-hydroxy amino acids have been synthesized via 1,3-dipolar cycloadditions of novel Z-nitrones and substituted olefins. Three achiral nitrones were synthesized in pursuit of a conformationally stable yet ...
Design of Photocage Ligands for Light-Activated Changes in Coordination of d-block Transition Metals

Ciesienski, Katie Lynnann (2010)

The concept of light-activated "caged" metal ions was first introduced for Ca2+. These high affinity coordination complexes are activated by UV light to release calcium ions intracellularly and have found widespread ...
Determination of the Kinetic and Chemical Mechanism of a Unique Peptidoglycan Recycling Enzyme with Dual Hydrolase and Kinase Functionality: Anhydromuramic Acid Kinase, AnmK

Clancy, Kathleen (2012)

Antibiotic resistance is a crisis in modern society causing increasing rates of bacterial infections impervious to current therapies. To this end, new targets for antimicrobial treatment ...
Developing Hybrid Material Interfaces for Microcontact Printing and Molecular Recognition

Bowers, Carleen Morris (2012)

Monomolecular hybrid organic-inorganic interfaces provide opportunities for applications in fields ranging from sensors to electronics. In this thesis, we report our efforts towards (1) developing a universal method for ...
Development and Application of a Mass Spectrometry-Based Assay for the High Throughput Analysis of Protein-Ligand Binding

Hopper, Erin D. (2009)

Many of the biological roles of proteins are modulated through protein-ligand interactions, making proteins important targets for drug therapies and diagnostic imaging probes. The discovery of novel ligands for a protein ...
Development and Application of Analytical Strategies to Facilitate Protein-Ligand Binding Analysis on the Proteomic Scale

Wang, Dongyu (2013)

SPROX (Stability of Proteins from Rates of Oxidation) is a technique for the detection and quantitation of protein-ligand binding interactions. In SPROX the differential denaturant dependence of a methionine oxidation ...
Development and Applications of Chemical Labeling Protocols for Protein-Ligand Binding Analysis Using Bottom-Up Proteomics

Xu, Ying (2011)

Proteins fold into well-defined three-dimensional structures to carry out their biological functions which involve non-covalent interactions with other cellular molecules. Knowledge about the thermodynamic properties ...
Development of a beta-Secretase Activated Prochelator and FRET Probe to Mediate Copper Toxicity in Alzheimer's Disease

Folk, Drew Steven (2012)

Alzheimer's disease (AD) is a progressive neurodegenerative disease that affects over 5 million people in the United States alone. This number is predicted to triple to by the year 2050 due to both increasing life ...
Development of Advanced MRI Methods for Improving Signal and Contrast in Biomedical Imaging Applications

Stokes, Ashley Marie (2012)

This dissertation reports advances in magnetic resonance imaging (MRI), with the ultimate goal of improving signal and contrast in biomedical applications. More specifically, novel MRI pulse sequences have been designed ...
Development of Fluorescent Iron and Copper Sensors Activated by Hydrogen Peroxide or Ultraviolet Light

Hyman, Lynne (2011)

Fluorescent sensors provide a powerful analytical tool for the intracellular detection of metal cations. In some cases, these fluorescent metal-chelating sensors have helped elucidate the function of metal cations ...
Development of Novel Physical Methods to Enhance Contrast and Sensitivity in Magnetic Resonance Imaging

Jenista, Elizabeth (2010)

The purpose of this thesis is to report technological developments in contrast mechanisms for MRI. The search for new forms of contrast is on-going, with the hope that new contrast mechanisms and new contrast agents ...