Browsing Electronic Theses and Dissertations by Subject "T cell"

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Effects of Dysregulated Diacylglycerol-Mediated Signaling on T Cell Function

Krishna, Sruti (2013)

<p>Diacylglycerol (DAG), a lipid messenger generated upon T cell receptor (TCR) engagement, mediates signaling through the IKK/NF-κB and Ras/ERK pathways. Further downstream of the Ras/ERK pathway are mammalian target ...
The Role of Glucose Metabolism in T Cell Stimulation and Homeostasis

Jacobs, Sarah Ruth (2009)

<p>The role of two cell extrinsic signals, T cell receptor (TCR) ligation and interleukin-7, in promoting glucose uptake and survival of T lymphocytes is examined in this work. Both of these signals are capable of regulating ...