Browsing Electronic Theses and Dissertations by Subject "V(D)J recombination"

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Mechanistic and Genetic Biases in Human Immunoglobulin Heavy Chain Development

Volpe, Joseph M (2008-04-23)

Broadly neutralizing antibodies against HIV are rare; most patients never develop them at detectable levels. The discovery of four such antibodies therefore warrants research into their origins and their presumed unique ...
The Role of Epigenetics in Regulating V(D)J Recombination and Allelic Exclusion

Kondilis-Mangum, Hrisavgi Demetrios (2011)

<p>As members of the adaptive immune response, T- and B- cells express unique antigen receptors generated from antigen receptor loci. These loci encode multiple Variable (V), Diversity (D), and Joining (J) gene segments. ...