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dc.contributor.advisor Izatt, Joseph A en_US
dc.contributor.author Zhao, Mingtao en_US
dc.date.accessioned 2009-12-18T16:26:36Z
dc.date.available 2011-12-31T05:30:07Z
dc.date.issued 2009 en_US
dc.identifier.uri http://hdl.handle.net/10161/1640
dc.description Dissertation en_US
dc.description.abstract <p>Spectral&#8208;domain optical&#8208;coherence tomography (SDOCT) has recently emerged as a powerful new tool for noninvasive human retinal imaging. I have developed a low&#8208;cost, high resolution real&#8208;time Spectral Domain Optical Coherence Tomography (SDOCT) system optimized for rapid 3D imaging of the human retina in vivo. Then functional retinal OCT imaging such as polarization sensitive OCT (PSOCT) and Doppler OCT were also developed based on phase technique. Unique phase unwrapping method in retina is described to extract the total reflectivity, accumulative retardance and fast axis orientation of the retinal nerve fiber layer (RNFL). The polarization scrambling layer of the retinal pigment epithelium was segmented by employing single camera sequential scan bsed PSOCT. As an extension, synthetic wavelength method will be also introduced for phase unwrapping in cell imaging. Finally I present an algorithm for 3D refraction correction based on a vector representation which accounts for refraction of CT light in the cornea. Following 3D refraction correction of volumetric corneal datasets, we can estimate the corneal optical power, thickness and the individual wavefront aberrations of the epithelial and the refraction&#8208;corrected endothelial surfaces by using Zernike spectrum analysis.</p> en_US
dc.format.extent 11806361 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.subject Engineering, Biomedical en_US
dc.subject anterior segment imaging en_US
dc.subject Doppler en_US
dc.subject Optical coherence tomography en_US
dc.subject Phase unwrapping en_US
dc.subject polarization en_US
dc.subject Retina en_US
dc.title Spectral Domain Optical Coherence Tomography System Development for in Vivo Ophthalmic Imaging  en_US
dc.type Dissertation en_US
dc.department Biomedical Engineering en_US
duke.embargo.months 24 en_US

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