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dc.contributor.advisor Matsunami, Hiroaki en_US
dc.contributor.author Roberts, Richard William en_US
dc.date.accessioned 2009-12-18T16:35:00Z
dc.date.available 2011-12-31T05:30:07Z
dc.date.issued 2009 en_US
dc.identifier.uri http://hdl.handle.net/10161/1660
dc.description Dissertation en_US
dc.description.abstract <p>The chemical cues that provide an olfactory portrait of mammalian individuals are in part detected by chemosensory receptors in the vomeronasal organ (VNO). By and large, the pertinent receptor-cue combinations used for olfactory communication are unidentified. Here we identify members of the formyl peptide receptor (FPR) family of G protein coupled receptors as candidate chemosensory receptors in the VNO of mice. We demonstrate that N-formylated mitochondrially encoded peptides presented by the major histocompatibility complex (MHC) molecule H2-M3 stimulate a subset of the VNO sensory neurons (VSNs). We show that one VNO localized FPR, Fpr-rs1, is differentially activated by strain specific variants of N-formylated peptides. We show that N-formylated peptides can function as chemosignals in a strain selective pregnancy block. We propose that this link between self-recognition peptides of the immune system and chemosensory pathways provides a possible molecular means to communicate the nature of an individual's maternal lineage or strain.</p> en_US
dc.format.extent 2194634 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.subject Biology, Molecular en_US
dc.subject Biology, Neuroscience en_US
dc.subject Biology, General en_US
dc.subject chemosignal en_US
dc.subject formyl peptide receptors en_US
dc.subject GPCRs en_US
dc.subject olfactory en_US
dc.subject pheromone en_US
dc.subject vomeronasal en_US
dc.title Maternally Inherited Peptides Are Strain Specific Chemosignals That Activate a New Candidate Class of Vomeronasal Chemosensory Receptor en_US
dc.type Dissertation en_US
dc.department Genetics and Genomics en_US
duke.embargo.months 24 en_US

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