Show simple item record

dc.contributor.advisor Hauser, Elizabeth en_US
dc.contributor.author Ou, Chern-Han en_US
dc.date.accessioned 2010-05-13T17:49:41Z
dc.date.available 2010-05-13T17:49:41Z
dc.date.issued 2010 en_US
dc.identifier.uri http://hdl.handle.net/10161/2501
dc.description Thesis en_US
dc.description.abstract <p>Variations in gene expression are potential risk factors for atherosclerosis, which is one of the most common forms of cardiovascular disease. We performed a localized Pearson correlation test in 372 individuals from seven datasets relevant to cardiovascular disease studies. The genomes of samples were separated into 20Mb windows and correlation tests were performed locally in these windows. The localized Pearson correlation test found chr3:115Mb&ndash;135Mb was tightly connected by significantly high proportion of highly correlated pairs (<italic>P</italic> value = 0.0266 with Z-test). LSAMP, GATA2, MBD4, and other genes in the region were considered associated with cardiovascular disease because they were involved in highly correlated pairs. Furthermore, these genes were also associated with cardiovascular disease by having significantly high SNP odds ratios (<italic>P</italic> value < 0.1) between patients and controls in an independent Duke University Medical Center database. In addition, a permutation test was performed to demonstrate that chr3:115Mb&ndash;135Mb might underlie the regulation of cardiovascular disease. Finally, the localized Pearson correlation test also found some other regions that could be associated with cardiovascular disease.</p> en_US
dc.format.extent 8483044 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US
dc.subject Biology, Bioinformatics en_US
dc.subject Biology, Genetics en_US
dc.subject Biology, Biostatistics en_US
dc.subject Cardiovascular Disease en_US
dc.subject Correlation en_US
dc.subject Gene expression en_US
dc.subject Genetics en_US
dc.subject Genomics en_US
dc.title Localized Correlation Analysis and Genetic Association with Cardiovascular Disease en_US
dc.type Thesis en_US
dc.department Computational Biology and Bioinformatics en_US

Files in this item

This item appears in the following Collection(s)

Show simple item record