Browsing Duke Faculty Scholarship by Duke-affiliated Author "Pegram, Charles"

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MRP3: a molecular target for human glioblastoma multiforme immunotherapy

Kuan, Chien-Tsun; Wakiya, Kenji; Pegram, Charles; Rasheed, Ahmed; Szafranski, Scott; McLendon, Roger; Bigner, Darell (BIOMED CENTRAL LTD, 2010)

Background: Glioblastoma multiforme (GBM) is refractory to conventional therapies. To overcome the problem of heterogeneity, more brain tumor markers are required for prognosis and targeted therapy. We have identified and ...
Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase-a key enzyme in lacto-neolacto ganglioside synthesis

Kuan, Chien-Tsun; Chang, Jinli; Li, Jianjun; Pegram, Charles; McLendon, Roger; Bigner, Darell (BIOMED CENTRAL LTD, 2010)

Background: Ganglioside biosynthesis occurs through a multi-enzymatic pathway which at the lactosylceramide step is branched into several biosynthetic series. Lc3 synthase utilizes a variety of galactose-terminated glycolipids ...