Antibodies specific for the β1-adrenergic receptor are found in patients with chronic heart failure of various etiologies. From work presented in this issue of the JCI, we can now infer that these antibodies actually ...

Morphine induces antinociception by activating μ opioid receptors (μORs) in spinal and supraspinal regions of the CNS. βarrestin-2 (βarr2), a G-protein-coupled receptor-regulating protein, regulates the μOR in vivo. We ...

The reinforcing and psychomotor effects of morphine involve opiate stimulation of the dopaminergic system via activation of μ-opioid receptors (μOR). Both μ-opioid and dopamine receptors are members of the G-protein-coupled ...

The beta-adrenergic receptor kinase (beta ARK) phosphorylates the agonist-occupied beta-adrenergic receptor to promote rapid receptor uncoupling from Gs, thereby attenuating adenylyl cyclase activity. Beta ARK-mediated ...

Heptahelical receptors, so called because of their conserved structure featuring seven α-helical transmembrane spans, mediate physiological responses to a remarkably diverse array of stimuli. These include hormones, ...

Human lymphocytes are known to possess a catecholamine-responsive adenylate cyclase which has typical P-adrenergic specificity. To identify directly and to quantitate these P-adrenergic receptors in human lymphocytes, (-) ...

Background Stimulation of β1- and β2-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the β3AR is also expressed in the human heart and that its stimulation leads ...

Background— Heart failure is characterized by abnormalities in β-adrenergic receptor (βAR) signaling, including increased level of myocardial βAR kinase 1 (βARK1). Our previous studies have shown that inhibition of βARK1 ...

I. Introduction RECEPTORS coupled to heterotrimeric GTP-binding proteins (G proteins) comprise the largest known family of cell surface receptors and mediate cellular responses to a diverse array of signaling molecules, ...