Browsing Duke Faculty Scholarship by Duke-affiliated Author "Crumbliss, Alvin L."

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Role of Citrate and Phosphate Anions in the Mechanism of Iron(III) Sequestration by Ferric Binding Protein: Kinetic Studies of the Formation of the Holoprotein of Wild-Type FbpA and Its Engineered Mutants

Weaver, Katherine D.; Gabricevic, Mario; Crumbliss, Al (AMER CHEMICAL SOC, 2010)

Ferric binding protein A (FbpA) plays a central role in the iron acquisition processes of pathogenic Neisseria gonorrheae, Neisseria meningitidis, and Haemophilus influenzae. FbpA functions as an iron shuttle within the ...
Synthesis and Iron Sequestration Equilibria of Novel Exocyclic 3-Hydroxy-2-pyridinone Donor Group Siderophore Mimics

Harrington, James; Dhungana, Suraj; Crumbliss, Al (AMER CHEMICAL SOC, 2010)

The synthesis of a novel class of exocyclic bis- and tris-3,2-hydroxypyridinone (HOPO) chelators built on N-2 and N-3 aza-macrocyclic scaffolds and the thermodynamic solution characterization of their complexes with Fe(III) ...