Browsing Duke Scholarly Works by Duke-affiliated Author "Beese, Lorena Sue"

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Structure-Based Design and Synthesis of Potent, Ethylenediamine-Based, Mammalian Farnesyltransferase Inhibitors as Anticancer Agents

Hast, Michael; Beese, Lorena (AMER CHEMICAL SOC, 2010)

A potent class of anticancer. human farnesyltransferase (111:Tase) inhibitors has been identified by "piggy-backing" on potent, antimalarial inhibitors of Plosmodium falciparum farnesyltransferase (P/FTase). On the basis ...