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Browsing Duke Faculty Scholarship by Duke-affiliated Author

Browsing Duke Faculty Scholarship by Duke-affiliated Author "Glower, Donald D. Jr."

Now showing items 1-3 of 3

Enhancement of cardiac function after adenoviral-mediated in vivo intracoronary β2-adrenergic receptor gene delivery

Maurice, John; Hata, Jonathan Andrew; Shah, Ashish; White, David Cloid; McDonald, Patricia; Dolber, Paul Christian; Wilson, Katrina; Lefkowitz, Robert J.; Glower, Donald D. Jr.; Koch, Walter J. (American Society for Clinical Investigation, 1999-07)

Exogenous gene delivery to alter the function of the heart is a potential novel therapeutic strategy for treatment of cardiovascular diseases such as heart failure (HF). Before gene therapy approaches to alter cardiac ...
Intracoronary Adenovirus-Mediated Delivery and Overexpression of the β2-Adrenergic Receptor in the Heart

Shah, Ashish; Lilly, R. Eric; Kypson, Alan; Tai, Oliver; Hata, Jonathan Andrew; Pippen, Anne; Silvestry, Scott Christopher; Lefkowitz, Robert J.; Glower, Donald D. Jr. (American Heart Association, 2000-02)

Background—Genetic modulation of ventricular function may offer a novel therapeutic strategy for patients with congestive heart failure. Myocardial overexpression of β2-adrenergic receptors (β2ARs) has been shown to enhance ...
In Vivo Ventricular Gene Delivery of a β-Adrenergic Receptor Kinase Inhibitor to the Failing Heart Reverses Cardiac Dysfunction

Shah, Ashish; White, David Cloid; Emani, Sitaram; Kypson, Alan; Lilly, R. Eric; Wilson, Katrina; Glower, Donald D. Jr.; Lefkowitz, Robert J.; Koch, Walter J. (American Heart Association, 2001-03)

Background—Genetic manipulation to reverse molecular abnormalities associated with dysfunctional myocardium may provide novel treatment. This study aimed to determine the feasibility and functional consequences of in vivo ...