Browsing Duke Faculty Scholarship by Author "0194314"

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Hybrid Transgenic Mice Reveal In Vivo Specificity of G Protein–Coupled Receptor Kinases in the Heart

Eckhart, Andrea Dawn; Duncan, Sandra; Lefkowitz, Robert J.; Koch, Walter J. (American Heart Association, 2000-01)

G protein–coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors, including α1B-adrenergic receptors (ARs), resulting in desensitization. In vivo analysis of GRK substrate selectivity has been ...
In Vivo Inhibition of Elevated Myocardial β-Adrenergic Receptor Kinase Activity in Hybrid Transgenic Mice Restores Normal β-Adrenergic Signaling and Function

Akhter, Shahab; Eckhart, Andrea Dawn; Shotwell, Kyle; Lefkowitz, Robert J.; Koch, Walter J. (American Heart Association, 1999-08)

Background Stimulation of β1- and β2-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the β3AR is also expressed in the human heart and that its stimulation leads ...