Browsing Duke Faculty Scholarship by Author "0310084"

Now showing items 1-5 of 5

Coordination of platinum therapeutic agents to met-rich motifs of human copper transport protein1

Crider, Sarah E.; Holbrook, Robert J.; Franz, Katherine (ROYAL SOC CHEMISTRY, 2010)

Platinum therapeutic agents are widely used in the treatment of several forms of cancer. Various mechanisms for the transport of the drugs have been proposed including passive diffusion across the cellular membrane and ...
Development of next-generation photolabile copper cages with improved copper binding properties

Ciesienski, Katie L.; Haas, Kathryn; Franz, Katherine (ROYAL SOC CHEMISTRY, 2010)

Seven new nitrogen-donor ligands that contain a photoactive nitrophenyl group within the ligand backbone have been prepared and evaluated for their binding affinity for copper(II) and zinc(II). Among this series, the ligand ...
Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease

Perez, Lissette; Franz, Katherine (ROYAL SOC CHEMISTRY, 2010)

Neurodegenerative diseases like Alzheimer's and Parkinson's disease are associated with elevated levels of iron, copper, and zinc and consequentially high levels of oxidative stress. Given the multifactorial nature of these ...
A Prochelator Activated by beta-Secretase Inhibits A beta Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation

Folk, Drew S.; Franz, Katherine (AMER CHEMICAL SOC, 2010)

The intersection of the amyloid cascade hypothesis and the implication of metal ions in Alzheimer's disease progression has sparked an interest in using metal-binding compounds as potential therapeutic agents. In the present ...
Toward the Detection of Cellular Copper(II) by a Light-Activated Fluorescence Increase

Ciesienski, Katie L.; Hyman, Lynne; Derisavifard, Samir; Franz, Katherine (AMER CHEMICAL SOC, 2010)

A new type of Cu2+ fluorescent sensor, courage, has been prepared with a photosensitive nitrophenyl group incorporated into the backbone of a coumarin-tagged tetradentate ligand. Coucage provides a selective fluorescence ...