Browsing Duke Faculty Scholarship by Duke-affiliated Author "Thiele, Dennis James"

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Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

Neef, Dr Daniel; Turski, Michelle L.; Thiele, Dennis (PUBLIC LIBRARY SCIENCE, 2010)

Neurodegenerative diseases such as Huntington disease are devastating disorders with no therapeutic approaches to ameliorate the underlying protein misfolding defect inherent to poly-glutamine (polyQ) proteins. Given the ...