Browsing Duke Faculty Scholarship by Author "0337824"

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β-Arrestin1 mediates nicotinic acid–induced flushing, but not its antilipolytic effect, in mice

Walters, Robert William; Shukla, Arun Kumar; Kovacs, Jeffrey J.; Violin, Jonathan David; DeWire, Scott Matthew; Lam, Christopher; Chen, Ruthie; Muehlbauer, Mike; Whalen, Eric; Lefkowitz, Robert J. (American Society for Clinical Investigation, 2009-05)

Nicotinic acid is one of the most effective agents for both lowering triglycerides and raising HDL. However, the side effect of cutaneous flushing severely limits patient compliance. As nicotinic acid stimulates the GPCR ...
β-Arrestins Regulate Atherosclerosis and Neointimal Hyperplasia by Controlling Smooth Muscle Cell Proliferation and Migration

Kim, Jihee; Zhang, Lisheng; Peppel, Karsten C.; Wu, Jiao-Hui; Zidar, David; Brian, Leigh; DeWire, Scott Matthew; Exum, Sabrina; Lefkowitz, Robert J.; Freedman, Neil Jonathan (American Heart Association, 2008-07)

Atherosclerosis and arterial injury-induced neointimal hyperplasia involve medial smooth muscle cell (SMC) proliferation and migration into the arterial intima. Because many 7-transmembrane and growth factor receptors ...