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Browsing Duke Faculty Scholarship by Author "0412374"

DukeSpace

Browsing Duke Faculty Scholarship by Author "0412374"

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  • The Characterization of Twenty Sequenced Human Genomes
    Pelak, Kimberly; Shianna, Kevin; Ge, Dr Dongliang; Maia, Jessica; Zhu, Dr Mingfu; Smith, Jason P.; Cirulli, Liz; Fellay, Dr Jacques; Dickson, Sam; Gumbs, Curtis; Heinzen, Erin L.; Need, Anna; Ruzzo, Elizabeth K.; Singh, Dr A; Campbell, Christopher; Hong, Linda; Lornsen, Katharina A.; McKenzie, Alexander; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)
    We present the analysis of twenty human genomes to evaluate the prospects for identifying rare functional variants that contribute to a phenotype of interest. We sequenced at high coverage ten "case" genomes from individuals ...
  • Common Genetic Variation and the Control of HIV-1 in Humans
    Fellay, Dr Jacques; Ge, Dr Dongliang; Shianna, Kevin; Cirulli, Liz; Urban, Thomas; Gumbs, Curtis; Feng, Sheng; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2009)
    To extend the understanding of host genetic determinants of HIV-1 control, we performed a genome-wide association study in a cohort of 2,554 infected Caucasian subjects. The study was powered to detect common genetic ...
  • Genome-Wide mRNA Expression Correlates of Viral Control in CD4+T-Cells from HIV-1-Infected Individuals
    Dang, Kristen; Fellay, Dr Jacques; Heinzen, Erin L.; Feng, Sheng; Shianna, Kevin; Ge, Dr Dongliang; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)
    There is great interindividual variability in HIV-1 viral setpoint after seroconversion, some of which is known to be due to genetic differences among infected individuals. Here, our focus is on determining, genome-wide, ...
  • Host Determinants of HIV-1 Control in African Americans
    Pelak, Kimberly; Goldstein, David; Walley, Nicole; Fellay, Dr Jacques; Ge, Dr Dongliang; Shianna, Kevin; Gumbs, Curtis; Maia, Jessica; Cronin, Ken (UNIV CHICAGO PRESS, 2010)
    We performed a whole-genome association study of human immunodeficiency virus type 1 (HIV-1) set point among a cohort of African Americans (n = 515), and an intronic single-nucleotide polymorphism (SNP) in the HLA-B gene ...
  • Screening the human exome: a comparison of whole genome and whole transcriptome sequencing
    Cirulli, Liz; Singh, Dr A; Shianna, Kevin; Ge, Dr Dongliang; Smith, Jason P.; Maia, Jessica; Heinzen, Erin L.; Goldstein, David (BIOMED CENTRAL LTD, 2010)
    Background: There is considerable interest in the development of methods to efficiently identify all coding variants present in large sample sets of humans. There are three approaches possible: whole-genome sequencing, ...
  • Whole-Genome Sequencing of a Single Proband Together with Linkage Analysis Identifies a Mendelian Disease Gene
    Cirulli, Liz; Ge, Dr Dongliang; Shianna, Kevin; Smith, Jason P.; Maia, Jessica; Gumbs, Curtis; Goldstein, David (PUBLIC LIBRARY SCIENCE, 2010)
    Although more than 2,400 genes have been shown to contain variants that cause Mendelian disease, there are still several thousand such diseases yet to be molecularly defined. The ability of new whole-genome sequencing ...