Browsing Duke Faculty Scholarship by Author "Akhremitchev, Boris B."

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Calcium Dependence of Fibrin Nanomechanics: The gamma 1 Calcium Mediates the Unfolding of Fibrinogen Induced by Force Applied to the "A-a" Bond

Akhremitchev, Boris B. (AMER CHEMICAL SOC, 2010)

The interactions between the constituent monomers of fibrin, the polymerized protein network that provides the structural stability of blood clots, ale frequently under stress because of the dynamic nature of blood flow ...
Distributions of Parameters and Features of Multiple Bond Ruptures in Force Spectroscopy by Atomic Force Microscopy

Guo, Senli; Li, Nan; Lad, Nimit; Desai, Shivam; Akhremitchev, Boris B. (AMER CHEMICAL SOC, 2010)

Force spectroscopy measurement of rupture forces of bound molecules becomes an important physicochemical tool in characterizing intermolecular interactions, Atomic force microscopy (AFM) measurements are among the most ...
Kinetic Parameters from Detection Probability in Single Molecule Force Spectroscopy

Ray, Chad; Guo, Senli; Brown, Dr Jason; Li, Nan; Akhremitchev, Boris B. (AMER CHEMICAL SOC, 2010)

The detection probability of rupture events in A FM force spectroscopy measurements presents a viable alternative to standard methods for extracting kinetic parameters of dissociation. The detection probability has a maximum ...
Mechanical Distortion of Protein Receptor Decreases the Lifetime of a Receptor-Ligand Bond

Guo, Senli; Li, Nan; Lad, Nimit; Ray, Chad; Akhremitchev, Boris B. (AMER CHEMICAL SOC, 2010)

Substantial experimental evidence indicates that the mechanical force applied to pull apart non-covalent molecular bonds (such as receptor ligand pairs) can significantly decrease the bond lifetime. This evidence is often ...