Browsing Duke Faculty Scholarship by Author "Allen, Kyle D."

Now showing items 1-3 of 3

Evaluating Intra-Articular Drug Delivery for the Treatment of Osteoarthritis in a Rat Model

Allen, Kyle D.; Adams, Samuel; Setton, Lori (MARY ANN LIEBERT INC, 2010)

Osteoarthritis (OA) is a degenerative joint disease that can result in joint pain, loss of joint function, and deleterious effects on activity levels and lifestyle habits. Current therapies for OA are largely aimed at ...
Gait and Behavior in an IL-1-Mediated Model of Rat Knee Arthritis and Effects of an IL1 Antagonist

Allen, Kyle D.; Adams, Samuel; Mata, Brian A.; Shamji, Mohammed F.; Gouze, Elvire; Jing, Liufang; Nettles, Dana; Latt, Dr Daniel; Setton, Lori (Journal of Orthopedic Research, 2011)

Objective: Interleukin-1 beta (IL1β) is a pro-inflammatory cytokine that mediates arthritic pathologies. Our objective was to evaluate pain and limb dysfunction resulting from IL1β over-expression in the rat knee and ...
Interleukin-17 synergizes with IFNγ or TNFα to promote inflammatory mediator release and intercellular adhesion molecule-1 (ICAM-1) expression in human intervertebral disc cells

Gabr, Mostafa A.; Jing, Liufang; Helbling, Antonia R.; Sinclair, S. Michael; Allen, Kyle D.; Shamji, Mohammed F.; Richardson, William; Fitch, Robert; Setton, Lori; Chen, Jun (Wiley Press, 2011-01-01)

Interleukin-17 (IL-17) is a cytokine recently shown to be elevated, along with interferon-γ (IFNγ) and tumor necrosis factor (TNFα), in degenerated and herniated intervertebral disc (IVD) tissues, suggesting a role for ...