Browsing Duke Scholarly Works by Author "Iaccarino, Guido"

Now showing items 1-3 of 3

Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy

Lefkowitz, Robert J.; Iaccarino, Guido; Koch, Walter J. (American Society for Clinical Investigation, 2001-04)

The medical treatment of chronic heart failure has undergone a dramatic transition in the past decade. Short-term approaches for altering hemodynamics have given way to long-term, reparative strategies, including ...
Reciprocal In Vivo Regulation of Myocardial G Protein-Coupled Receptor Kinase Expression by b-Adrenergic Receptor Stimulation and Blockade

Lefkowitz, Robert J.; Koch, Walter J.; Tomhave, Eric; Iaccarino, Guido (American Heart Association, 1998)

Background—Impaired myocardial β-adrenergic receptor (βAR) signaling, including desensitization and functional uncoupling, is a characteristic of congestive heart failure. A contributing mechanism for this impairment may ...
β-Adrenergic Receptor Kinase-1 Levels in Catecholamine-Induced Myocardial Hypertrophy

Iaccarino, Guido; Dolber, Paul Christian; Lefkowitz, Robert J.; Koch, Walter J. (American Heart Association, 1999-01)

Pressure overload ventricular hypertrophy is accompanied by dysfunctional β-adrenergic receptor signaling due to increased levels of the β-adrenergic receptor kinase-1, which phosphorylates and desensitizes β-adrenergic ...