Browsing Duke Scholarly Works by Author "Ray, Chad"

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Kinetic Parameters from Detection Probability in Single Molecule Force Spectroscopy

Ray, Chad; Guo, Senli; Brown, Dr Jason; Li, Nan; Akhremitchev, Boris B. (AMER CHEMICAL SOC, 2010)

The detection probability of rupture events in A FM force spectroscopy measurements presents a viable alternative to standard methods for extracting kinetic parameters of dissociation. The detection probability has a maximum ...
Mechanical Distortion of Protein Receptor Decreases the Lifetime of a Receptor-Ligand Bond

Guo, Senli; Li, Nan; Lad, Nimit; Ray, Chad; Akhremitchev, Boris B. (AMER CHEMICAL SOC, 2010)

Substantial experimental evidence indicates that the mechanical force applied to pull apart non-covalent molecular bonds (such as receptor ligand pairs) can significantly decrease the bond lifetime. This evidence is often ...