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Browsing Duke Faculty Scholarship by Subject "activation"

Now showing items 1-9 of 9

CD20 deficiency in humans results in impaired T cell-independent antibody responses

Tedder, Thomas F. (AMER SOC CLINICAL INVESTIGATION INC, 2010)

CD20 was the first B cell differentiation antigen identified, and CD20-specific mAbs are commonly used for the treatment of B cell malignancies and autoantibody-mediated autoimmune diseases. Despite this the role of CD20 ...
Co-regulation of nuclear respiratory factor-1 by NF kappa B and CREB links LPS-induced inflammation to mitochondrial biogenesis

Suliman, Hagir; Sweeney, Timothy; Withers, Crystal M.; Piantadosi, Claude (COMPANY OF BIOLOGISTS LTD, 2010)

The nuclear respiratory factor-1 (NRF1) gene is activated by lipopolysaccharide (LPS), which might reflect TLR4-mediated mitigation of cellular inflammatory damage via initiation of mitochondrial biogenesis. To test this ...
Differential Inhibition of Human Immunodeficiency Virus Type 1 in Peripheral Blood Mononuclear Cells and TZM-bl Cells by Endotoxin-Mediated Chemokine and Gamma Interferon Production

Geonnotti, Anthony R.; Bilska, Mira; Yuan, Xing; Montefiori, David (MARY ANN LIEBERT INC, 2010)

Bacterial lipopolysaccharide ( endotoxin) is a frequent contaminant of biological specimens and is also known to be a potent inducer of beta-chemokines and other soluble factors that inhibit HIV-1 infection in vitro. Though ...
Emi2-mediated Inhibition of E2-substrate Ubiquitin Transfer by the Anaphase-promoting Complex/Cyclosome through a D-Box-independent Mechanism

Tang, Wanli; Wu, Judy Qiju; Chen; Yang, Chih-Sheng; Guo, Jessie Yanxiang; Freel, Christopher; Kornbluth, Sally (AMER SOC CELL BIOLOGY, 2010)

Vertebrate eggs are arrested at Metaphase II by Emi2, the meiotic anaphase-promoting complex/cyclosome (APC/C) inhibitor. Although the importance of Emi2 during oocyte maturation has been widely recognized and its regulation ...
Epithelial-mesenchymal transitions and hepatocarcinogenesis

Jou, Janice; Diehl, Anna Mae (AMER SOC CLINICAL INVESTIGATION INC, 2010)

Epithelial-mesenchymal transitions (EMTs) are believed to play a role in invasion and metastasis of many types of tumors. In this issue of the JCI, Chen et al. show that a gene that has been associated with aggressive ...
Latent Factor Analysis to Discover Pathway-Associated Putative Segmental Aneuploidies in Human Cancers

Lucas, Joseph; Kung, Hsiu-Ni; Chi, Jen-Tsan A. (PUBLIC LIBRARY SCIENCE, 2010)

Tumor microenvironmental stresses, such as hypoxia and lactic acidosis, play important roles in tumor progression. Although gene signatures reflecting the influence of these stresses are powerful approaches to link expression ...
Mono- or Double-Site Phosphorylation Distinctly Regulates the Proapoptotic Function of Bax

Wang, Qinhong (PUBLIC LIBRARY SCIENCE, 2010)

Bax is the major multidomain proapoptotic molecule that is required for apoptosis. It has been reported that phosphorylation of Bax at serine(S) 163 or S184 activates or inactivates its proapoptotic function, respectively. ...
Porcine Endothelial Cells Cocultured with Smooth Muscle Cells Became Procoagulant In Vitro

Pang, Zhengyu; Niklason, Laura E.; Truskey, George (MARY ANN LIEBERT INC, 2010)

Endothelial cell (EC) seeding represents a promising approach to provide a nonthrombogenic surface on vascular grafts. In this study, we used a porcine EC/smooth muscle cell (SMC) coculture model that was previously developed ...
Solid-State and Dynamic Solution Behavior of a Cationic, Two-Coordinate Gold(I) pi-Allene Complex

Brown, Timothy J.; Sugie, Atsushi; Dickens, Marina G.; Widenhoefer, Ross (AMER CHEMICAL SOC, 2010)

The cationic gold pi-allene complex {[P(t-Bu)(2)o-biphenyl]Au[eta(2)-H2C-C-C(CH3)(2)]}(+) SbF6- was isolated in 98% yield from reaction of 3-methyl-1,2-butadiene with a mixture of [P(t-Bu)(2)o-biphenyl]AuCl and AgSbF6 and ...