Browsing Duke Faculty Scholarship by Subject "cancer-cells"

Now showing items 1-3 of 3

Development of next-generation photolabile copper cages with improved copper binding properties

Ciesienski, Katie L.; Haas, Kathryn; Franz, Katherine (ROYAL SOC CHEMISTRY, 2010)

Seven new nitrogen-donor ligands that contain a photoactive nitrophenyl group within the ligand backbone have been prepared and evaluated for their binding affinity for copper(II) and zinc(II). Among this series, the ligand ...
DNA Adducts of Decarbamoyl Mitomycin C Efficiently Kill Cells without Wild-Type p53 Resulting from Proteasome-Mediated Degradation of Checkpoint Protein 1

Hunter, Senyene; Meye, Joel (AMER CHEMICAL SOC, 2010)

The mitomycin derivative 10-decarbamoyl mitomycin C (DMC) more rapidly activates a p53-independent cell death pathway than mitomycin C (MC). We recently documented that an increased proportion of mitosenel-beta-adduct ...
Modulation of Heat Shock Transcription Factor 1 as a Therapeutic Target for Small Molecule Intervention in Neurodegenerative Disease

Neef, Dr Daniel; Turski, Michelle L.; Thiele, Dennis (PUBLIC LIBRARY SCIENCE, 2010)

Neurodegenerative diseases such as Huntington disease are devastating disorders with no therapeutic approaches to ameliorate the underlying protein misfolding defect inherent to poly-glutamine (polyQ) proteins. Given the ...