Browsing Duke Faculty Scholarship by Subject "hydrogen-peroxide"

Now showing items 1-3 of 3

Altered Gene Expression and DNA Damage in Peripheral Blood Cells from Friedreich's Ataxia Patients: Cellular Model of Pathology

Meyer, Joel (PUBLIC LIBRARY SCIENCE, 2010)

The neurodegenerative disease Friedreich's ataxia ( FRDA) is the most common autosomal-recessively inherited ataxia and is caused by a GAA triplet repeat expansion in the first intron of the frataxin gene. In this disease, ...
Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease

Perez, Lissette; Franz, Katherine (ROYAL SOC CHEMISTRY, 2010)

Neurodegenerative diseases like Alzheimer's and Parkinson's disease are associated with elevated levels of iron, copper, and zinc and consequentially high levels of oxidative stress. Given the multifactorial nature of these ...
A Prochelator Activated by beta-Secretase Inhibits A beta Aggregation and Suppresses Copper-Induced Reactive Oxygen Species Formation

Folk, Drew S.; Franz, Katherine (AMER CHEMICAL SOC, 2010)

The intersection of the amyloid cascade hypothesis and the implication of metal ions in Alzheimer's disease progression has sparked an interest in using metal-binding compounds as potential therapeutic agents. In the present ...