Browsing Duke Faculty Scholarship by Subject "ketones"

Now showing items 1-3 of 3

Development of a Strategy for the Asymmetric Synthesis of Polycyclic Polyprenylated Acylphloroglucinols via N-Amino Cyclic Carbamate Hydrazones: Application to the Total Synthesis of (+)-Clusianone

Garnsey, Michelle R.; Lim, Daniel; Yost, Julianne M.; Coltart, Dr Don (AMER CHEMICAL SOC, 2010)

A broadly applicable asymmetric synthetic strategy utilizing N-amino cyclic carbamate alkylation that provides access to the various stereochemical permutations of a common structural motif found in many polycyclic ...
Direct Carbon-Carbon Bond Formation via Reductive Soft Enolization: A Kinetically Controlled syn-Aldol Addition of alpha-Halo Thioesters and Enolizable Aldehydes

Sauer, Scott; Garnsey, Michelle R.; Coltart, Dr Don (AMER CHEMICAL SOC, 2010)

The direct addition of enolizable aldehydes and a-halo thioesters to produce beta-hydroxy thioesters enabled by reductive soft enolization is reported. The transformation is operationally simple and efficient and has the ...
Direct carbon-carbon bond formation via soft enolization: aldol addition of alpha-halogenated thioesters

Yost, Julianne M.; Alfie, Rachel J.; Tarsis, Emily; Chong, Insun; Coltart, Dr Don (ROYAL SOC CHEMISTRY, 2011)

alpha-Halo thioesters undergo soft enolization and syn-selective direct aldol addition to aldehydes in the presence of MgBr2 center dot OEt2 and i-Pr2NEt to produce alpha-halo-beta-hydroxy thioesters.