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Browsing Duke Scholarly Works by Subject "mutation"

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Association between DNA Damage Response and Repair Genes and Risk of Invasive Serous Ovarian Cancer

Schildkraut, Joellen; Moorman, Patricia (PUBLIC LIBRARY SCIENCE, 2010)

Background: We analyzed the association between 53 genes related to DNA repair and p53-mediated damage response and serous ovarian cancer risk using case-control data from the North Carolina Ovarian Cancer Study (NCOCS), ...
Genetic Signatures in the Envelope Glycoproteins of HIV-1 that Associate with Broadly Neutralizing Antibodies

Li, Ming; Tang, Haili; Greene, Kelli; Gao, Hongmei; Montefiori, David (PUBLIC LIBRARY SCIENCE, 2010)

A steady increase in knowledge of the molecular and antigenic structure of the gp120 and gp41 HIV-1 envelope glycoproteins (Env) is yielding important new insights for vaccine design, but it has been difficult to translate ...
A novel mutation of the ACADM gene (c.145C > G) associated with the common c.985A > G mutation on the other ACADM allele causes mild MCAD deficiency: a case report

Millington, David (BIOMED CENTRAL LTD, 2010)

A female patient, with normal familial history, developed at the age of 30 months an episode of diarrhoea, vomiting and lethargy which resolved spontaneously. At the age of 3 years, the patient re-iterated vomiting, was ...
Slip-Sliding Away: Serial Changes and Homoplasy in Repeat Number in the Drosophila yakuba Homolog of Human Cancer Susceptibility Gene BRCA2

Bennett, Sarah; Mercer, John; Noor, Mohamed (PUBLIC LIBRARY SCIENCE, 2010)

Several recent studies have examined the function and evolution of a Drosophila homolog to the human breast cancer susceptibility gene BRCA2, named dmbrca2. We previously identified what appeared to be a recent expansion ...