DukeSpace Home
→
Duke Faculty Scholarship
→
Browsing Duke Faculty Scholarship by Subject

Browsing Duke Faculty Scholarship by Subject "myocardium"

Now showing items 1-6 of 6

Arterial pole progenitors interpret opposing FGF/BMP signals to proliferate or differentiate

Hutson, Mary; Zeng, Xiaopei Lily; Kim, Andrew; Antoon, Emily; Harward, Stephen; Kirby, Margaret (COMPANY OF BIOLOGISTS LTD, 2010)

During heart development, a subpopulation of cells in the heart field maintains cardiac potential over several days of development and forms the myocardium and smooth muscle of the arterial pole. Using clonal and explant ...
A dual role for ErbB2 signaling in cardiac trabeculation

Kikuchi, Kazu; Poss, Ken (COMPANY OF BIOLOGISTS LTD, 2010)

Cardiac trabeculation is a crucial morphogenetic process by which clusters of ventricular cardiomyocytes extrude and expand into the cardiac jelly to form sheet-like projections. Although it has been suggested that cardiac ...
Implantation of Mouse Embryonic Stem Cell-Derived Cardiac Progenitor Cells Preserves Function of Infarcted Murine Hearts

Christoforou, Nicolas; Bian, Weining; Bursac, Nenad; Leong, Kam (PUBLIC LIBRARY SCIENCE, 2010)

Stem cell transplantation holds great promise for the treatment of myocardial infarction injury. We recently described the embryonic stem cell-derived cardiac progenitor cells (CPCs) capable of differentiating into ...
Intracoronary Adenovirus-Mediated Delivery and Overexpression of the β2-Adrenergic Receptor in the Heart

Shah, Ashish; Lilly, R. Eric; Kypson, Alan; Tai, Oliver; Hata, Jonathan Andrew; Pippen, Anne; Silvestry, Scott Christopher; Lefkowitz, Robert J.; Glower, Donald D. Jr. (American Heart Association, 2000-02)

Background—Genetic modulation of ventricular function may offer a novel therapeutic strategy for patients with congestive heart failure. Myocardial overexpression of β2-adrenergic receptors (β2ARs) has been shown to enhance ...
In Vivo Inhibition of Elevated Myocardial β-Adrenergic Receptor Kinase Activity in Hybrid Transgenic Mice Restores Normal β-Adrenergic Signaling and Function

Akhter, Shahab; Eckhart, Andrea Dawn; Shotwell, Kyle; Lefkowitz, Robert J.; Koch, Walter J. (American Heart Association, 1999-08)

Background Stimulation of β1- and β2-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the β3AR is also expressed in the human heart and that its stimulation leads ...
Reciprocal In Vivo Regulation of Myocardial G Protein-Coupled Receptor Kinase Expression by b-Adrenergic Receptor Stimulation and Blockade

Lefkowitz, Robert J.; Koch, Walter J.; Tomhave, Eric; Iaccarino, Guido (American Heart Association, 1998)

Background—Impaired myocardial β-adrenergic receptor (βAR) signaling, including desensitization and functional uncoupling, is a characteristic of congestive heart failure. A contributing mechanism for this impairment may ...