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Browsing Duke Faculty Scholarship by Subject "oxidative stress"

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Altered Gene Expression and DNA Damage in Peripheral Blood Cells from Friedreich's Ataxia Patients: Cellular Model of Pathology

Meyer, Joel (PUBLIC LIBRARY SCIENCE, 2010)

The neurodegenerative disease Friedreich's ataxia ( FRDA) is the most common autosomal-recessively inherited ataxia and is caused by a GAA triplet repeat expansion in the first intron of the frataxin gene. In this disease, ...
Development of next-generation photolabile copper cages with improved copper binding properties

Ciesienski, Katie L.; Haas, Kathryn; Franz, Katherine (ROYAL SOC CHEMISTRY, 2010)

Seven new nitrogen-donor ligands that contain a photoactive nitrophenyl group within the ligand backbone have been prepared and evaluated for their binding affinity for copper(II) and zinc(II). Among this series, the ligand ...
Gene expression in developing fibres of Upland cotton (Gossypium hirsutum L.) was massively altered by domestication

Flagel, Lex (BIOMED CENTRAL LTD, 2010)

Background: Understanding the evolutionary genetics of modern crop phenotypes has a dual relevance to evolutionary biology and crop improvement. Modern upland cotton (Gossypium hirsutum L.) was developed following thousands ...
Growth Factor erv1-like Modulates Drp1 to Preserve Mitochondrial Dynamics and Function in Mouse Embryonic Stem Cells

Horn, Sarah; Means, Anthony (AMER SOC CELL BIOLOGY, 2010)

The relationship of mitochondrial dynamics and function to pluripotency are rather poorly understood aspects of stem cell biology. Here we show that growth factor erv1-like (Gfer) is involved in preserving mouse embryonic ...
Homeostatic Imbalance of Purine Catabolism in First-Episode Neuroleptic-Naive Patients with Schizophrenia

McEvoy, Joseph; Kaddurah-Daouk, Dr Rima (PUBLIC LIBRARY SCIENCE, 2010)

Background: Purine catabolism may be an unappreciated, but important component of the homeostatic response of mitochondria to oxidant stress. Accumulating evidence suggests a pivotal role of oxidative stress in schizophrenia ...
Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP through MondoA

Chen, Julia Ling-Yu; Wu, Jianli; Liu, Patrick Yantyng; Chi, Jen-Tsan (PUBLIC LIBRARY SCIENCE, 2010)

Although lactic acidosis is a prominent feature of solid tumors, we still have limited understanding of the mechanisms by which lactic acidosis influences metabolic phenotypes of cancer cells. We compared global transcriptional ...
Minding metals: Tailoring multifunctional chelating agents for neurodegenerative disease

Perez, Lissette; Franz, Katherine (ROYAL SOC CHEMISTRY, 2010)

Neurodegenerative diseases like Alzheimer's and Parkinson's disease are associated with elevated levels of iron, copper, and zinc and consequentially high levels of oxidative stress. Given the multifactorial nature of these ...
Molecular characterization of numr-1 and numr-2: genes that increase both resistance to metal-induced stress and lifespan in Caenorhabditis elegans

Tvermoes, Brooke E. (COMPANY OF BIOLOGISTS LTD, 2010)

To define the mechanisms involved in the molecular response to the carcinogenic metal cadmium, two novel metal-inducible genes from C. elegans were characterized: numr-1 and numr-2 (nuclear localized metal responsive). ...
Water exchange rates of water-soluble manganese(III) porphyrins of therapeutical potential

Batinic-Haberle, Ines (ROYAL SOC CHEMISTRY, 2010)

The activation parameters and the rate constants of the water-exchange reactions of (MnTE)-T-III-2-PyP5+ (meso-tetrakis(N-ethylpyridinium-2-yl) porphyrin) as cationic, Mn(III)TnHex-2-PyP5+ (meso-tetrakis(N-n-hexylpyridinium-2-yl) ...