Browsing Duke Faculty Scholarship by Subject "t-cell depletion"

Now showing items 1-3 of 3

The Humoral Response to HIV-1: New Insights, Renewed Focus

Alter, Galit; Moody, Tony (UNIV CHICAGO PRESS, 2010)

During the past 2 decades, significant advances in our understanding of the humoral immune response to human immunodeficiency virus type 1 (HIV-1) infection have been made, yet a tremendous amount of work lies ahead. Despite ...
Inhibition of Adaptive Immune Responses Leads to a Fatal Clinical Outcome in SIV-Infected Pigtailed Macaques but Not Vervet African Green Monkeys

Li, Ming; Tang, Haili; Montefiori, David (PUBLIC LIBRARY SCIENCE, 2009)

African green monkeys (AGM) and other natural hosts for simian immunodeficiency virus (SIV) do not develop an AIDS-like disease following SIV infection. To evaluate differences in the role of SIV-specific adaptive immune ...
R5 Clade C SHIV Strains with Tier 1 or 2 Neutralization Sensitivity: Tools to Dissect Env Evolution and to Develop AIDS Vaccines in Primate Models

Montefiori, David (PUBLIC LIBRARY SCIENCE, 2010)

Background: HIV-1 clade C (HIV-C) predominates worldwide, and anti-HIV-C vaccines are urgently needed. Neutralizing antibody (nAb) responses are considered important but have proved difficult to elicit. Although some current ...