Browsing Duke Faculty Scholarship by Subject "tumor-cell"

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DNA Adducts of Decarbamoyl Mitomycin C Efficiently Kill Cells without Wild-Type p53 Resulting from Proteasome-Mediated Degradation of Checkpoint Protein 1

Hunter, Senyene; Meye, Joel (AMER CHEMICAL SOC, 2010)

The mitomycin derivative 10-decarbamoyl mitomycin C (DMC) more rapidly activates a p53-independent cell death pathway than mitomycin C (MC). We recently documented that an increased proportion of mitosenel-beta-adduct ...