Browsing Duke Scholarly Works by Subject "yeast"

Now showing items 1-3 of 3

Bayesian Variable Selection in Structured High-Dimensional Covariate Spaces With Applications in Genomics

Li, Fan (AMER STATISTICAL ASSOC, 2010)

We consider the problem of variable selection in regression modeling in high-dimensional spaces where there is known structure among the covariates. This is an unconventional variable selection problem for two reasons: (1) ...
Identification and Inhibitory Properties of a Novel Ca2+/Calmodulin Antagonist

Colomer, Josep; Means, Anthony (AMER CHEMICAL SOC, 2010)

We developed a high-throughput yeast-based assay to screen for chemical inhibitors of Ca2+/calmodulin-dependent kinase pathways. After screening two small libraries, we identified the novel antagonist 125-C9, a substituted ...
PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90

Zaas, Dr Aimee; Schell, Wiley; Betancourt-Quiroz, Marisol; Perfect, John (PUBLIC LIBRARY SCIENCE, 2010)

Fungal pathogens exploit diverse mechanisms to survive exposure to antifungal drugs. This poses concern given the limited number of clinically useful antifungals and the growing population of immunocompromised individuals ...