Browsing Duke Faculty Articles by Duke-affiliated Author "Hellinga, Homme Wytzes"

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Thermodynamic Analysis of Ligand-Induced Changes in Protein Thermal Unfolding Applied to High-Throughput Determination of Ligand Affinities with Extrinsic Fluorescent Dyes

Layton, Curtis J.; Hellinga, Homme (AMER CHEMICAL SOC, 2010)

The quantification of protein ligand interactions is essential for systems biology, drug discovery, and bioengineering. Ligand-induced changes in protein thermal stability provide a general, quantifiable signature of binding ...