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Browsing Duke Faculty Articles by Duke-affiliated Author "Chao, Nelson Jen An"

Now showing items 1-4 of 4

Diagnosis of Partial Body Radiation Exposure in Mice Using Peripheral Blood Gene Expression Profiles

Meadows, Sarah K.; Daher, Pamela; Himburg, Heather; Russell, J. Lauren; Doan, Dr Phuong; Chao, Nelson; Chute, Dr John (PUBLIC LIBRARY SCIENCE, 2010)

In the event of a terrorist-mediated attack in the United States using radiological or improvised nuclear weapons, it is expected that hundreds of thousands of people could be exposed to life-threatening levels of ionizing ...
Gene Expression Signatures of Radiation Response Are Specific, Durable and Accurate in Mice and Humans

Meadows, Sarah K.; Muramoto, Garrett G.; Himburg, Heather; Salter, Alice; Chao, Nelson; Chute, Dr John (PUBLIC LIBRARY SCIENCE, 2008)

Background: Previous work has demonstrated the potential for peripheral blood (PB) gene expression profiling for the detection of disease or environmental exposures. Methods and Findings: We have sought to determine the ...
Growth Hormone Mitigates against Lethal Irradiation and Enhances Hematologic and Immune Recovery in Mice and Nonhuman Primates

Chen, Benny; Deoliveira, Divino; Spasojevic, Ivan; Sempowski, Gregory; Wang, Xiaojuan; Gesty-Palmer, Diane; Meadows, Sarah K.; Daher, Pamela; Muramoto, Garrett; Chute, Dr John; Chao, Nelson (PUBLIC LIBRARY SCIENCE, 2010)

Medications that can mitigate against radiation injury are limited. In this study, we investigated the ability of recombinant human growth hormone (rhGH) to mitigate against radiation injury in mice and nonhuman primates. ...
Selective Enhancement of Donor Hematopoietic Cell Engraftment by the CXCR4 Antagonist AMD3100 in a Mouse Transplantation Model

Kang, Yubin; Chen, Benny; Deoliveira, Divino; Mito, Jeffrey; Chao, Nelson Jen An (PLoS ONE, 2010-06)

The interaction between stromal cell-derived factor-1 (SDF-1) with CXCR4 chemokine receptors plays an important role in hematopoiesis following hematopoietic stem cell transplantation. We examined the efficacy of post ...