Browsing Duke Faculty Articles by Author "0223027"

Now showing items 1-5 of 5

Augmentation of Cardiac Contractility Mediated by the Human β3-Adrenergic Receptor Overexpressed in the Hearts of Transgenic Mice

Kohout, Trudy; Takaoka, Hideyuki; McDonald, Patricia; Perry, Stephen; Mao, Lan; Lefkowitz, Robert J.; Rockman, Howard Allan (American Heart Association, 2001-11)

Background Stimulation of β1- and β2-adrenergic receptors (ARs) in the heart results in positive inotropy. In contrast, it has been reported that the β3AR is also expressed in the human heart and that its stimulation leads ...
Catecholamines, Cardiac β-Adrenergic Receptors, and Heart Failure

Lefkowitz, Robert J.; Rockman, Howard Allan; Koch, Walter J. (American Heart Association, 2000-04)
Level of β-Adrenergic Receptor Kinase 1 Inhibition Determines Degree of Cardiac Dysfunction After Chronic Pressure Overload–Induced Heart Failure

Tachibana, Hideo; Naga Prasad, Sathyamangla; Lefkowitz, Robert J.; Rockman, Howard Allan (American Heart Association, 2005-02)

Background— Heart failure is characterized by abnormalities in β-adrenergic receptor (βAR) signaling, including increased level of myocardial βAR kinase 1 (βARK1). Our previous studies have shown that inhibition of βARK1 ...
When 7 transmembrane receptors are not G protein–coupled receptors

Rajagopal, Keshava; Lefkowitz, Robert J.; Rockman, Howard Allan (American Society for Clinical Investigation, 2005-11)

Classically, 7 transmembrane receptors transduce extracellular signals by coupling to heterotrimeric G proteins, although recent in vitro studies have clearly demonstrated that they can also signal via G protein–independent ...
β-Arrestin–mediated β1-adrenergic receptor transactivation of the EGFR confers cardioprotection

Noma, Takahisa; Lemaire, Anthony; Prasad, Sathyamangla V. Naga; Barki-Harrington, Liza; Tilley, Douglas; Chen, Juhsien; Le Corvoisier, Philippe; Violin, Jonathan David; Wei, Huijin; Lefkowitz, Robert J.; Rockman, Howard Allan (American Society for Clinical Investigation, 2007-09)

Deleterious effects on the heart from chronic stimulation of β-adrenergic receptors (βARs), members of the 7 transmembrane receptor family, have classically been shown to result from Gs-dependent adenylyl cyclase activation. ...